Current advances for bone regeneration based on tissue engineering strategies

  • Rui Shi
  • Yuelong Huang
  • Chi Ma
  • Chengai Wu
  • Wei TianEmail author


Bone tissue engineering (BTE) is a rapidly developing strategy for repairing critical-sized bone defects to address the unmet need for bone augmentation and skeletal repair. Effective therapies for bone regeneration primarily require the coordinated combination of innovative scaffolds, seed cells, and biological factors. However, current techniques in bone tissue engineering have not yet reached valid translation into clinical applications because of several limitations, such as weaker osteogenic differentiation, inadequate vascularization of scaffolds, and inefficient growth factor delivery. Therefore, further standardized protocols and innovative measures are required to overcome these shortcomings and facilitate the clinical application of these techniques to enhance bone regeneration. Given the deficiency of comprehensive studies in the development in BTE, our review systematically introduces the new types of biomimetic and bifunctional scaffolds. We describe the cell sources, biology of seed cells, growth factors, vascular development, and the interactions of relevant molecules. Furthermore, we discuss the challenges and perspectives that may propel the direction of future clinical delivery in bone regeneration.


bone tissue engineering stem cell bone scaffold growth factor bone regeneration 


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This work was supported by the National Natural Science Foundation of China (Nos. 51673029, 81330043, and 81071499), Beijing Talent Fund (No. 2016000021223ZK34), and another fund (No. PXM2018_026275_000001).


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Copyright information

© Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Rui Shi
    • 1
  • Yuelong Huang
    • 2
  • Chi Ma
    • 1
  • Chengai Wu
    • 1
  • Wei Tian
    • 1
    • 2
    Email author
  1. 1.Institute of Traumatology and Orthopaedics, Beijing Laboratory of Biomedical MaterialsBeijing Jishuitan HospitalBeijingChina
  2. 2.Department of Spine Surgery of Beijing Jishuitan HospitalThe Fourth Clinical Medical College of Peking UniversityBeijingChina

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