Frontiers of Medicine

, Volume 12, Issue 3, pp 262–268 | Cite as

γδ T cells in liver diseases

  • Xuefu WangEmail author
  • Zhigang Tian


γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit liver-specific features. Accumulating evidence reveals that γδ T cells play important roles in liver infection, non-alcoholic fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regeneration. In this study, we review the properties of hepatic γδ T cells and summarize the roles of γδ T cells in liver diseases. We believe that determining the properties and functions of γδ T cells in liver diseases enhances our understanding of the pathogenesis of liver diseases and is useful for the design of novel γδ T cell-based therapeutic regimens for liver diseases.


γδT cells liver infection non-alcoholic fatty liver disease autoimmune hepatitis liver fibrosis and cirrhosis liver cancer liver regeneration 


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This work was supported by the Anhui Natural Science Foundation (No. 1708085QH183), Natural Science Foundation of China (Nos. 81302863, 31390433, and 91542000), and the Ministry of Science and Technology of China (973 Program, No. 2013CB944902).


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Copyright information

© Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of PharmacyAnhui Medical UniversityHefeiChina
  2. 2.Institute of Immunology and CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical CenterUniversity of Science and Technology of ChinaHefeiChina
  3. 3.Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of MedicineZhejiang UniversityHangzhouChina

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