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Frontiers of Medicine

, Volume 11, Issue 3, pp 440–444 | Cite as

Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of 18F-FDG PET/CT

  • Zhan Su
  • Fengyu Wu
  • Weiyu Hu
  • Xiaodan Liu
  • Shaoling Wu
  • Xianqi Feng
  • Zhongguang Cui
  • Jie Yang
  • Zhenguang Wang
  • Hongzai Guan
  • Hongguo Zhao
  • Wei Wang
  • Chunting ZhaoEmail author
  • Jun PengEmail author
Case Report

Abstract

Philadelphia chromosome-positive acute myeloid leukemia is controversial and difficult to distinguish from the blast phase of chronic myeloid leukemia. As a myeloid neoplasm, rare cases of this leukemia manifest multiple soft-tissue tumors or bone lytic lesions. In this paper, we describe a 49-year-old male patient who had an abrupt onset with sharp chest pain, fever, fatigue, emaciation, and splenomegaly. 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) result showed diffuse and uneven hypermetabolic lesions in the bone marrow with peripheral bone marrow expansion, multiple soft tissue neoplasms with high 18F-FDG uptake, and lytic bone lesions. Bone marrow smear and biopsy detected aberrant blast cells expressing myeloid rather than lymphoid immunophenotype marker. For the existence of Philadelphia chromosome and BCR-ABL1 fusion gene together with complex chromosome abnormalities, a diagnosis of Philadelphia-positive acute myeloid leukemia was made, although the type (de novo or blast crisis) remained unclear.

Keywords

Philadelphia chromosome acute myeloid leukemia mass osteolysis positron emission tomography 

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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Zhan Su
    • 1
    • 2
  • Fengyu Wu
    • 3
  • Weiyu Hu
    • 4
  • Xiaodan Liu
    • 2
  • Shaoling Wu
    • 2
  • Xianqi Feng
    • 2
  • Zhongguang Cui
    • 2
  • Jie Yang
    • 2
  • Zhenguang Wang
    • 3
  • Hongzai Guan
    • 5
  • Hongguo Zhao
    • 2
  • Wei Wang
    • 2
  • Chunting Zhao
    • 2
    Email author
  • Jun Peng
    • 1
    Email author
  1. 1.Department of Haematology, Qilu HospitalShandong UniversityJinanChina
  2. 2.Department of HaematologyThe Affiliated Hospital of Qingdao UniversityQingdaoChina
  3. 3.PET/CT CenterThe Affiliated Hospital of Qingdao UniversityQingdaoChina
  4. 4.Department of Hepatobiliary SurgeryThe Affiliated Hospital of Qingdao UniversityQingdaoChina
  5. 5.Department of HaematologyQingdao University Medical CollegeQingdaoChina

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