Frontiers of Medicine

, Volume 7, Issue 3, pp 306–315

Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation



Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective options for hematological malignancies, and human leukocyte antigen-partially matched related donors (PMRDs) are a valuable option for HSCT. Several protocols (with or without ex vivo T-cell depletion (TCD)) have been established worldwide. TCD including CD34+ positive selection and CD3/CD19 depletion has successfully overcome the human leukocyte antigen disparity. However, TCD is associated with prolonged immune deficiencies, increased risks of infectious complications, and high transplantation-related mortality. PMRD HSCTwithout ex vivo TCD is well developed, and numerous patients have benefitted from it. Here, we review the literature on PMRD HSCT.


partially matched related donor hematopoietic stem cell transplantation allogeneic 


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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Peking University People’s Hospital & Institute of HematologyBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijingChina

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