Frontiers of Medicine

, Volume 6, Issue 4, pp 376–380 | Cite as

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

  • Fung Zhao
  • Eric W. -F. Lam


The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.


FOXO3a FOXM1 transcription factor cancer drug resistance tumorigenesis 


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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Surgery and CancerImperial College LondonLondonUK

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