High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience
- 265 Downloads
High-intensity focused ultrasound (HIFU) is a technique to destroy tissue at depth within the body, selectively and without harming overlying and adjacent structures within the path of the beam because the ultrasonic intensity at the beam focus is much higher than that outside of the focus. Diagnostic ultrasound is the first imaging modality used for guiding HIFU ablation. In 1997, a patient with osteosarcoma was first successfully treated with ultrasound imaging-guided HIFU in Chongqing, China. Over the last decade, thousands of patients with uterine fibroids, liver cancer, breast cancer, pancreatic cancer, bone tumors, and renal cancer have been treated with ultrasound imaging-guided HIFU. Based on several research groups’ reports, as well as our ten-year clinical experience, we conclude that this technique is safe and effective in treating human solid tumors. HIFU is a promising technique. Most importantly, HIFU offers patients another alternative when those patients have no other treatment available.
Keywordshigh-intensity focused ultrasound (HIFU) ultrasound imaging-guided HIFU (USgHIFU) magnetic resonance imaging-guided HIFU (MRgHIFU)
Unable to display preview. Download preview PDF.
- 5.Wu F, Wang Z B, Chen W Z, Wang W, Gui Y, Zhang M, Zheng G, Zhou Y, Xu G, Li M, Zhang C, Ye H, Feng R. Extracorporeal high intensity focused ultrasound ablation in the treatment of 1038 patients with solid carcinomas in China: an overview. Ultrason Sonochem, 2004, 11(3–4): 149–154CrossRefPubMedGoogle Scholar
- 6.Zhang L, Chen W Z, Liu Y J, Hu X, Zhou K, Chen L, Peng S, Zhu H, Zou H L, Bai J, Wang Z B. Feasibility of magnetic resonance imaging-guided high intensity focused ultrasound therapy for ablating uterine fibroids in patients with bowel lies anterior to uterus. Eur J Radiol, 2010, 73(2): 396–403CrossRefPubMedGoogle Scholar
- 14.Chen W, Zhou K. High-intensity focused ultrasound ablation: a new strategy to manage primary bone tumors. Curr Opin Orthop, 2006, 16(6): 494–500Google Scholar
- 18.Wenzhi C, Rhee S, Wei W, Bai L, Zhou J, Hui Z, Wang Z, Wu F, Li K, Zhou K. Comparison of clinical outcome of osteosarcomas after treatment of surgery and HIFU. In: Proceedings of the 6th International Symposium on Therapeutic Ultrasound, 2006Google Scholar
- 22.Illing R O, Kennedy J E, Wu F, ter Haar G R, Protheroe A S, Friend P J, Gleeson F V, Cranston D W, Phillips R R, Middleton M R. The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population. Br J Cancer, 2005, 93(8): 890–895CrossRefPubMedGoogle Scholar
- 24.Orsi F, Zhang L, Arnone P, Bonomo G, Vigna P D, Monfardini L, Zhou K, Chen W Z, Wang Z B, Veronesi U. High intensity focused ultrasound (HIFU) ablation: Effective and safe therapy for solid tumors at difficult locations. AJR Am J Roentgenol, (in press)Google Scholar
- 26.Wang X, Sun J. High-intensity focused ultrasound in patients with late-stage pancreatic carcinoma. Chin Med J (Engl), 2002, 115(9): 1332–1335Google Scholar
- 35.Wang W, Liu W Y, Zhou J M, Xu J M, Gai L H, Huang C J. High-intensity focused ultrasound treatment for symptomatic uterine fibroids: Preliminary results. Zhonghua Chao Sheng Ying Xiang Xue Za Zhi, 2002, 11(3): 161–163 (in Chinese)Google Scholar
- 36.He H, Lu L, Zhou Y, Nie Y. Clinical study of curing uterine leiomyoma with high intensity focused ultrasound. Zhongguo Xian Dai Yi Xue Za Zhi, 2004, 14(19): 9 (in Chinese)Google Scholar
- 37.Wang Y, Wang W, Wang L, Wang J, Tang J. Ultrasound-guided high-intensity focused ultrasound treatment for abdominal wall endometriosis: Preliminary results. Eur J Radiol, 2010 Jan 28. doi:10.1016/j.ejrad.2009.12.034Google Scholar