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Frontiers of Medicine in China

, Volume 4, Issue 3, pp 303–307 | Cite as

Difference between 2 h and 3 h 75 g glucose tolerance test in the diagnosis of gestational diabetes mellitus (GDM): Results from a national survey on prevalence of GDM

  • Xue-Lian Gao
  • Yu-Mei Wei
  • Hui-Xia YangEmail author
  • Xian-Ming Xu
  • Ling Fan
  • Jing He
  • Ning Liu
  • San-Cun Zhao
  • Ya-Li Hu
  • Zi Yang
  • Yun-Ping Zhang
  • Xing-Hui Liu
  • Xu Chen
  • Jian-Ping Zhang
  • Wen-Li Gou
  • Mei Xiao
  • Hai-Rong Wu
  • Mei-Hua Zhang
Research Article

Abstract

The possibility of the 2 h oral glucose tolerance test (OGTT) as an alternative to the 3 h OGTT was investigated based on data from a national survey on pregnancy-associated diabetes. Data were retrieved from 4179 pregnant women who had OGTT performed after an abnormal 50 g glucose challenge test (GCT). All of the 4 glucose levels during their OGTT were collected and analyzed. According to American Diabetes Association (ADA) gestational diabetes mellitus (GDM) diagnostic criteria, among the 4179 pregnant women who required OGTT, 3429 (82.1%) were normal and 750 (17.9%) were diagnosed as GDM. If the 3rd h glucose levels were omitted from OGTT, 79 cases of GDM (10.5%) would be overlooked. No trend was shown where women with more risk factors were more likely to be overlooked if the 3rd h test was omitted (χ2 for trend = 0.038, P > 0.05). No significant differences were found in the rate of cesarean section (CS), preterm births or macrosomia between the 79 cases and those with normal OGTT results and in the gestational weeks when OGTT was performed. It shows that in order to diagnose one woman with GDM, another 52 pregnant women would have an innocent 3rd h glucose test. Omission of the 3rd h glucose test in OGTT might be reasonable due to its convenience, better compliance and a small number of possibly miss-diagnosed cases, and their pregnancy outcomes have no significant difference from those of normal pregnant women.

Keywords

diabetes gestational oral glucose tolerance test 

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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Xue-Lian Gao
    • 1
  • Yu-Mei Wei
    • 1
  • Hui-Xia Yang
    • 1
    Email author
  • Xian-Ming Xu
    • 2
  • Ling Fan
    • 3
  • Jing He
    • 4
  • Ning Liu
    • 5
  • San-Cun Zhao
    • 6
  • Ya-Li Hu
    • 7
  • Zi Yang
    • 8
  • Yun-Ping Zhang
    • 9
  • Xing-Hui Liu
    • 10
  • Xu Chen
    • 11
  • Jian-Ping Zhang
    • 12
  • Wen-Li Gou
    • 13
  • Mei Xiao
    • 14
  • Hai-Rong Wu
    • 15
  • Mei-Hua Zhang
    • 16
  1. 1.Department of Obstetrics and GynecologyPeking University First HospitalBeijingChina
  2. 2.Department of Obstetrics and Gynecology, First Affiliated People’s HospitalShanghai Jiao Tong UniversityShanghaiChina
  3. 3.Department of Obstetrics, Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijingChina
  4. 4.Women’s Hospital, School of MedicineZhejiang UniversityHangzhouChina
  5. 5.Maternal and Child Health Care Hospital of UrumchiUrumchiChina
  6. 6.Maternal and Child Health Care Hospital of ShanxiXi’anChina
  7. 7.Department of Obstetrics and Gynecologythe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingChina
  8. 8.Peking University Third HospitalBeijingChina
  9. 9.Maternal and Child Health Care Hospital of Haidian DistrictBeijingChina
  10. 10.Department of Obstetrics and Gynecology, West China Second University HospitalSichuan UniversityChengduChina
  11. 11.Tianjin Central Hospital of Obstetrics and GynecologyTianjinChina
  12. 12.Department of Obstetrics and Gynecology, the Second Affiliated HospitalSun Yat-sen UniversityGuangzhouChina
  13. 13.Department of Obstetrics and Gynecology, the First Affiliated HospitalMedical School of Xi’an Jiaotong UniversityShanxiChina
  14. 14.Department of Obstetrics and GynecologyHubei Maternal & Child Health HospitalWuhanChina
  15. 15.The Central Hospital of Aviation Industry of ChinaBeijingChina
  16. 16.Taiyuan Maternal and Infant Health Care Hospital of Shanxi ProvinceTaiyuanChina

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