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Neuroanatomical and functional alterations of insula in mild traumatic brain injury patients at the acute stage

  • Fengfang Li
  • Liyan Lu
  • Huiyou Chen
  • Peng Wang
  • Hong Zhang
  • Yu-Chen ChenEmail author
  • Xindao YinEmail author
ORIGINAL RESEARCH
  • 44 Downloads

Abstract

Cognitive impairment is a major cause of disability and decline in quality of life in mild traumatic brain injury (mTBI) survivors, but the underlying pathophysiology is still poorly understood. The insula has extensive connections to other cortex and is believed to responsible for integrating external and internal processes and controlling cognitive functions. To explore this hypothesis, we investigated early alterations in the gray matter volume (GMV) and brain functional connectivity (FC) of insula in mTBI patients within 7 days after injury and any possible correlations with cognitive function. A total of 58 mTBI patients at the acute stage and 32 matched healthy controls were recruited and underwentT1-weighted magnetic resonance imaging (MRI)andresting-state functional MRI scans within 7 days of injury. FC was characterized using seed-based region of interest analysis method. The patients’ cognitive function was evaluated with Montreal Cognitive Assessment (MoCA) score. The resulting of GMV and FC of insula were correlated with cognitive alterations. We found that the GMV was significantly reduced only in the right insula in mTBI patients and no significant GMV increase was observed in either hemisphere. mTBI patients demonstrated decreased FC in the right parahippocampal gyrus and increased FC in the right supramargianl gyrus. In addition, compared to the healthy controls, the mTBI patients in the acute stage presented a decline in the visuospatial/executive (p = 0.013) and attention (p = 0.038) subcategories. In the mTBI group, the changes in GMV in the right insula were positively correlated with poor attention performance (r = 0.316, p = 0.016). Our data demonstrated alterations of the GMV and resting-stateFC of the right insula in mTBI patients at the acute stage. These early changes in GMV and resting-state FC perhaps serve as a potential biomarker for improving the understanding of cognitive decline for mTBI in the acute setting.

Keywords

Mild traumatic brain injury Gray matter volume Functional connectivity Cognitive function MRI 

Notes

Funding

This work was supported by the National Natural Science Foundation of China (No.81870563), Jiangsu Provincial Special Program of Medical Science (BE2017614), Youth Medical Talents of Jiangsu Province (No. QNRC2016062), 14th “Six Talent Peaks” Project of Jiangsu Province (No. YY-079), and the Nanjing Medical University grant (No. 2017NJMU123).

Compliance with ethical standards

Conflict of interests

The authors declare that there is no potential conflict of interests regarding the publication of this paper.

Ethical approval

The current study was approved by the Research Ethics Committee of the Nanjing Medical University.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Authors and Affiliations

  1. 1.Department of Radiology, Nanjing First HospitalNanjing Medical UniversityNanjingChina
  2. 2.Department of RadiologyThe Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjingChina

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