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Brain Imaging and Behavior

, Volume 12, Issue 6, pp 1795–1803 | Cite as

Difference in regional neural fluctuations and functional connectivity in Crohn’s disease: a resting-state functional MRI study

  • Chunhui Bao
  • Peng Liu
  • Huirong Liu
  • Xiaoming Jin
  • Yin Shi
  • Luyi Wu
  • Xiaoqing Zeng
  • Jianye Zhang
  • Di Wang
  • Vince D. Calhoun
  • Jie Tian
  • Huangan Wu
Original Research

Abstract

Patients with Crohn’s disease (CD) are shown to have abnormal changes in brain structures. This study aimed to further investigate whether these patients have abnormal brain activities and network connectivity. Sixty patients with CD and 40 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (fMRI) scans. Amplitude of low-frequency fluctuation (ALFF) and seed-based functional connectivity (FC) were used to assess differences in spontaneous regional brain activity and functional connectivity. Compared to the HCs, patients with CD showed significantly higher ALFF values in hippocampus and parahippocampus (HIPP/paraHIPP), anterior cingulate cortex, insula, superior frontal cortex and precuneus. The ALFF values were significantly lower in secondary somatosensory cortex (S2), precentral gyrus, and medial prefrontal cortex. Functional connectivities between left HIPP and left inferior temporal cortex, and right middle cingulate cortex, HIPP, and fusiform area were significantly lower. The functional connectivities between right HIPP and right inferior orbitofrontal cortex and left HIPP were also significantly lower. Patients with CD showed higher or lower spontaneous activity in multiple brain regions. Altered activities in these brain regions may collectively reflect abnormal function and regulation of visceral pain and sensation, external environmental monitoring, and cognitive processing in these patients. Lower functional connectivity of the hippocampus-limbic system was observed in these patients. These findings may provide more information to elucidate the neurobiological mechanisms of the disease.

Keywords

Crohn’s disease Resting-state functional MRI Amplitude of low-frequency fluctuation Functional connectivity 

Notes

Acknowledgements

Many thanks to Dr. Lili Ma at Zhongshan Hospital of Fudan University for endoscopy examination and scoring. This work was funded by the National Key Basic Research Program of China (973 program), No. 2009CB522900, 2015CB554501; the Program for Outstanding Medical Academic Leader, No. 80; the Program of Shanghai Academic Research Leader, No. 17XD1403400, the National Natural Science Foundation of China, No. 81471738 and the National Institutes of Health grant (P20GM103472).

Compliance with ethical standards

Conflict of interest

The authors disclose no conflicts.

Research involving human participants

All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from every participant included in the study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Chunhui Bao
    • 1
  • Peng Liu
    • 2
  • Huirong Liu
    • 3
  • Xiaoming Jin
    • 4
  • Yin Shi
    • 3
  • Luyi Wu
    • 1
  • Xiaoqing Zeng
    • 5
  • Jianye Zhang
    • 6
  • Di Wang
    • 1
  • Vince D. Calhoun
    • 7
    • 8
  • Jie Tian
    • 2
  • Huangan Wu
    • 1
  1. 1.Key Laboratory of Acupuncture and Immunological EffectsShanghai University of Traditional Chinese MedicineShanghaiChina
  2. 2.Life Sciences Research Center, School of Life Sciences and TechnologyXidian UniversityXi’anChina
  3. 3.Outpatient Department, Shanghai Research Institute of Acupuncture and MeridianShanghai University of Traditional Chinese MedicineShanghaiChina
  4. 4.Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisUSA
  5. 5.Department of Gastroenterology, Zhongshan HospitalFudan UniversityShanghaiChina
  6. 6.Department of Radiology, Shanghai Mental Health CenterShanghai Jiaotong University School of MedicineShanghaiChina
  7. 7.The Mind Research NetworkAlbuquerqueUSA
  8. 8.Department of Electrical and Computer EngineeringUniversity of New MexicoAlbuquerqueUSA

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