The important role of dACC in shyness
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Shyness is often characterized by the avoidance of social contact, the fear of other people’s evaluations and a lack of self-esteem. Generally, individuals with high levels of shyness are more likely to suffer from psychosomatic stress and social anxiety. However, the structural brain basis of individual shyness among healthy people has not yet been investigated with DTI (diffusion tensor imaging). Thus, in this study, we investigated the relationship between FA (fractional anisotropy), WMV (white matter volume), GMV (gray matter volume) and shyness in a large healthy sample of 318 college students. Multiple regression was used to analyze the correlations among regional FA, WMV, GMV and shyness, adjusting for age, sex, and total intracranial volume. The results showed that shyness was significantly, negatively associated with FA, WMV and GMV in a cluster that included the dACC (dorsal anterior cingulate cortex) and the MCC (middle cingulate cortex) and was significantly positively associated with the GMV in the IPL (inferior parietal lobule), an effect that may have been related to the weaker ability to regulate emotion in these participants and their state of being overly worried about others’ evaluations. Finally, mediation analyses revealed that the correlation between shyness and psychosomatic stress was mediated by a region including the dACC and the MCC.
KeywordsShyness Diffusion tensor imaging Dorsal anterior cingulate cortex Inferior parietal lobule
This research was supported by the National Natural Science Foundation of China (31470981; 31571137; 31500885; 31600878; 31771231), Project of the National Defense Science and Technology Innovation Special Zone, Chang Jiang Scholars Program, National Outstanding Young People Plan, the Program for the Top Young Talents by Chongqing, the Fundamental Research Funds for the Central Universities (SWU1609177), Natural Science Foundation of Chongqing (cstc2015jcyjA10106), Fok Ying Tung Education Foundation (151023), the Research Program Funds of the Collaborative Innovation Center of Assessment toward Basic Education Quality at Beijing Normal University.
Compliance with ethical standards
This study was approved by the local ethics committee of Southwest China University and the Institutional Human Participants Review Board of the Southwest University Imaging Center for Brain Research. The methods were conducted in accordance with the approved guidelines. All participants provided written informed consent prior to taking part in the study.
Conflict of interest
All authors declare that they have no conflict of interest.
Animal studies and human participants
All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
This article does not contain any studies with human participants performed by any of the authors.
Informed consent was obtained from all individual participants included in the study.
- Adamec, R. (1997). Transmitter systems involved in neural plasticity undelying increased anxiety and defense—implications for understanding anxiety following traumatic stress. Neuroscience & Biobehavioral Reviews, 21(6), 755–765.Google Scholar
- Beaton, E. A., Schmidt, L. A., Schulkin, J., & Hall, G. B. (2010). Neural correlates of implicit processing of facial emotions in shy adults. Personality and Individual Differences, 49(7), 755–761.Google Scholar
- Beidel, D. C., & Turner, S. M. (2007). Shy children, phobic adults: Nature and treatment of social anxiety disorder. DC: American Psychological Association Washington.Google Scholar
- Buss, S. R. (1986). Bounded arithmetic (Vol. 86). Bibliopolis Napoli.Google Scholar
- Chak, K., & Leung, L. (2004). Shyness and locus of control as predictors of internet addiction and internet use. Cyberpsychology & Behavior, 7(5), 559–570.Google Scholar
- Cheek, J. M., & Buss, A. H. (1981). Shyness and sociability. Journal of Personality and Social Psychology, 41(2), 330–339.Google Scholar
- Cheek, J. M., & Melchior, L. A. (1990). Shyness, self-esteem, and self-consciousness Handbook of social and evaluation anxiety (pp. 47-82). Springer.Google Scholar
- Chen, S.-H., et al. (2002). Trauma and psychosocial aftermath among high-and low-exposure adults three months post the 921 Chi-Chi earthquake in Taiwan. Chinese Journal of Psychology, 44(2), 167–188.Google Scholar
- Cohen, R. A., Grieve, S., Hoth, K. F., Paul, R. H., Sweet, L., Tate, D., Gunstad, J., Stroud, L., McCaffery, J., Hitsman, B., Niaura, R., Clark, C. R., MacFarlane, A., Bryant, R., Gordon, E., & Williams, L. M. (2006). Early life stress and morphometry of the adult anterior cingulate cortex and caudate nuclei. Biological Psychiatry, 59(10), 975–982.PubMedGoogle Scholar
- Comfort, S., & Phobia, S. (nd). Social anxiety/shyness.Google Scholar
- Costa, P. T., & MacCrae, R. R. (1992a). NEO PI-R: Professional Kit: Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI). Odessa: Psychological Assessment Resources.Google Scholar
- Costa Jr, P., & MacCrae, R. (1992b). Manual for the Revised NEO Personality Inventory (NEO-PIR) and the NEO Five-Factor Inventory (NEO-FFI). Odessa, FL: Psychological Assessment Resources: Inc.Google Scholar
- Cui, Z., Zhong, S., Xu, P., Gong, G., & He, Y. (2013). PANDA: a pipeline toolbox for analyzing brain diffusion images. Frontiers in human neuroscience, 7, 42.Google Scholar
- Domesick, V. B. (1970). The fasciculus cinguli in the rat. Brain Research, 20(1), 19–32.Google Scholar
- Drevets, W. C., Price, J. L., Simpson Jr, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997). Subgenual prefrontal cortex abnormalities in mood disorders. Nature, 386(6627), 824.Google Scholar
- Ebeling-Witte, S., Frank, M. L., & Lester, D. (2007). Shyness, internet use, and personality. Cyberpsychology & Behavior, 10(5), 713–716.Google Scholar
- Good, C.D., et al. (2002). A voxel-based morphometric study of ageing in 465 normal adult human brains. Biomedical Imaging, 2002. 5th IEEE EMBS International Summer School on, IEEE.Google Scholar
- Henderson, L., & Zimbardo, F. (1998). Syness. Encyclopedia of mental health. San Diego: Academic Press.Google Scholar
- Henriksen, R. E., & Murberg, T. A. (2009). Shyness as a risk-factor for somatic complaints among Norwegian adolescents. School Psychology International, 30(2), 148–162.Google Scholar
- Hiscock, M., Inch, R., Jacek, C., Hiscock-kalil, C., & Kalil, K. M. (1994). Is there a sex difference in human laterality? I. An exhaustive survey of auditory laterality studies from six neuropsychology journals. Journal of Clinical and Experimental Neuropsychology, 16(3), 423–435.PubMedGoogle Scholar
- Marcoulides, G., & Hershberger, S. (1997). Multivariate statistical analysis: A first course: Lawrence Erlbaum Associates, Mahwah, NJ.Google Scholar
- Onoda, K., Okamoto, Y., Nakashima, K.’., Nittono, H., Yoshimura, S., Yamawaki, S., Yamaguchi, S., & Ura, M. (2010). Does low self-esteem enhance social pain? The relationship between trait self-esteem and anterior cingulate cortex activation induced by ostracism. Social Cognitive and Affective Neuroscience, 5(4), 385–391.PubMedPubMedCentralGoogle Scholar
- Pilkonis, P. A. (1977). Shyness, public and private, and its relationship to other measures of social behavior1. Journal of Personality, 45(4), 585–595.Google Scholar
- Radua, J., Phillips, M. L., Russell, T., Lawrence, N., Marshall, N., Kalidindi, S., el-Hage, W., McDonald, C., Giampietro, V., Brammer, M. J., David, A. S., & Surguladze, S. A. (2010). Neural response to specific components of fearful faces in healthy and schizophrenic adults. Neuroimage, 49(1), 939–946.PubMedGoogle Scholar
- Smith, S. M., & Nichols, T. E. (2009). Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage, 44(1), 83–98.Google Scholar
- Smith, S. M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T. E., Mackay, C. E., Watkins, K. E., Ciccarelli, O., Cader, M. Z., Matthews, P. M., & Behrens, T. E. J. (2006). Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage, 31(4), 1487–1505.PubMedGoogle Scholar
- Tang, Y., Wang, F., Xie, G., Liu, J., Li, L., Su, L., Liu, Y., Hu, X., He, Z., & Blumberg, H. P. (2007). Reduced ventral anterior cingulate and amygdala volumes in medication-naive females with major depressive disorder: a voxel-based morphometric magnetic resonance imaging study. Psychiatry Research: Neuroimaging, 156(1), 83–86.PubMedGoogle Scholar
- Ward, C. C., & Tracey, T. J. (2004). Relation of shyness with aspects of online relationship involvement. Journal of Social and Personal Relationships, 21(5), 611–623.Google Scholar
- Yang, X., Wang, S., Kendrick, K. M., Wu, X., Yao, L., Lei, D., Kuang, W., Bi, F., Huang, X., He, Y., & Gong, Q. (2015). Sex differences in intrinsic brain functional connectivity underlying human shyness. Social Cognitive and Affective Neuroscience, 10(12), 1634–1643.PubMedPubMedCentralGoogle Scholar