Opposite subgenual cingulate cortical functional connectivity and metabolic activity patterns in refractory melancholic major depression
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Although in treatment-resistant depression (TRD) subgenual anterior cingulate cortex (sgACC) functional connectivity (FC) is frequently used to examine deregulated brain networks, neurobiological data from other sources may be required to interpret these FC findings. In 16 melancholic TRD patients with a high level of treatment resistance and 16 closely matched healthy never-depressed individuals we verified whether sgACC FC patterns were related to regional metabolic activity (CMRglc) with 18FDG PET imaging. Notwithstanding that TRD patients displayed stronger sgACC FC with the right lateral frontotemporal cortex, metabolically they exhibited the opposite pattern. Our results indicate that the sgACC seed and its functionally connected regions not automatically follow a similar metabolic pattern in TRD, possibly reflecting the refractory state of the sample. Multimodal brain imaging may help to increase our insight into the pathophysiology of TRD.
KeywordsMajor depressive disorder Refractory, sgACC Resting state fMRI, 18FDG PET
This study was funded by a grant from the Scientific Fund W. Gepts, by the Ghent University Multidisciplinary Research Partnership “The integrative neuroscience of behavioural control”, by a grant BOF16/GOA/017 for a Concerted Research Action of Ghent University, and by a grant from the National Natural Foundation of China (Grant No. 61876156).
Compliance with ethical standards
Conflict of interest
All authors report no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- Backes, H., Walberer, M., Endepols, H., Neumaier, B., Graf, R., Wienhard, K., et al. (2011). Whiskers area as extracerebral reference tissue for quantification of rat brain metabolism using (18)F-FDG PET: Application to focal cerebral ischemia. Journal of Nuclear Medicine, 52, 1252–1260.CrossRefPubMedGoogle Scholar
- Baeken, C., Van Schuerbeek, P., De Raedt, R., Ramsey, N. F., Bossuyt, A., De Mey, J., et al. (2010). Reduced left subgenual anterior cingulate cortical activity during withdrawal-related emotions in melancholic depressed female patients. Journal of Affective Disorders, 127, 326–331.CrossRefPubMedGoogle Scholar
- Baeken, C., Marinazzo, D., Wu, G. R., Van Schuerbeek, P., De Mey, J., Marchetti, I., et al. (2014). Accelerated HF-rTMS in treatment-resistant unipolar depression: Insights from subgenual anterior cingulate functional connectivity. World Journal of Biological Psychiatry, 15, 286–297.CrossRefPubMedGoogle Scholar
- Baeken, C., Marinazzo, D., Everaert, H., Wu, G. R., Van Hove, C., Audenaert, K., et al. (2015). The impact of accelerated HF-rTMS on the Subgenual anterior cingulate cortex in refractory unipolar major depression: Insights from 18FDG PET brain imaging. Brain Stimulation, 8, 808–815.CrossRefPubMedGoogle Scholar
- Beck, A. T., & Steer, R. A. (1984). Internal consistencies of the original and revised Beck depression inventory. Journal of Clinical Neurophysiology, 40, 1365–1367.Google Scholar
- Brett, M., Anton, J-L., Valabregue, R. (2002). Region of interest analysis using an SPM toolbox [abstract]. Presented at the Eighth international conference of functional mapping of the human brain, June 2–6, 2002, Sendai, Japan, vol. 16(2). Available on CD-ROM in NeuroImage 2002.Google Scholar
- Cisler, J. M., James, G. A., Tripathi, S., Mletzko, T., Heim, C., Hu, X. P., et al. (2013). Differential functional connectivity within an emotion regulation neural network among individuals resilient and susceptible to the depressogenic effects of early life stress. Psychological Medicine, 43, 507–518.CrossRefPubMedGoogle Scholar
- Dambacher, F., Sack, A. T., Lobbestael, J., Arntz, A., Brugmann, S., & Schuhmann, T. (2014). The role of right prefrontal and medial cortex in response inhibition: Interfering with action restraint and action cancellation using transcranial magnetic brain stimulation. Journal of Cognitive Neuroscience, 26, 1775–1784.CrossRefPubMedGoogle Scholar
- Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., et al. (2007). Resting-state functional connectivity in major depression: Abnormally increased contributions from subgenual cingulate cortex and thalamus. Biological Psychiatry, 62, 429–437.CrossRefPubMedCentralPubMedGoogle Scholar
- Ji, G.-J., Liao, W., Chen, F.-F., Zhang, L., & Wang, K. (2017). Low-frequency blood oxygen level-dependent fluctuations in the brain white matter: More than just noise. Scientific Bulletin, 62, 656–657.Google Scholar
- Li, J., Duan, X., Cui, Q., Chen, H., & Liao, W. (in press, 2018). More than just statics: Temporal dynamics of intrinsic brain activity predicts the suicidal ideation in depressed patients. Psycholological Medicine. https://doi.org/10.1017/S0033291718001502.
- Matthews, S. C., Strigo, I. A., Simmons, A. N., Yang, T. T., & Paulus, M. P. (2008). Decreased functional coupling of the amygdala and supragenual cingulate is related to increased depression in unmedicated individuals with current major depressive disorder. Journal of Affective Disorders, 111, 13–20.CrossRefPubMedGoogle Scholar
- Pflanz, C. P., Pringle, A., Filippini, N., Warren, M., Gottwald, J., Cowen, P. J., et al. (2015). Effects of seven-day diazepam administration on resting-state functional connectivity in healthy volunteers: A randomized, double-blind study. Psychopharmacology (Berlin), 232, 2139–2147.CrossRefGoogle Scholar
- Sheehan, D. V., Lecrubier, Y., Sheehan, K. H., Amorim, P., Janavs, J., Weiller, E., et al. (1998). The Mini-international neuropsychiatric interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry, 20, 22–57.Google Scholar