Working memory capacity and the functional connectome - insights from resting-state fMRI and voxelwise centrality mapping

  • Sebastian Markett
  • Martin Reuter
  • Behrend Heeren
  • Bernd Lachmann
  • Bernd Weber
  • Christian Montag
Original Research

Abstract

The functional connectome represents a comprehensive network map of functional connectivity throughout the human brain. To date, the relationship between the organization of functional connectivity and cognitive performance measures is still poorly understood. In the present study we use resting-state functional magnetic resonance imaging (fMRI) data to explore the link between the functional connectome and working memory capacity in an individual differences design. Working memory capacity, which refers to the maximum amount of context information that an individual can retain in the absence of external stimulation, was assessed outside the MRI scanner and estimated based on behavioral data from a change detection task. Resting-state time series were analyzed by means of voxelwise degree and eigenvector centrality mapping, which are data-driven network analytic approaches for the characterization of functional connectivity. We found working memory capacity to be inversely correlated with both centrality in the right intraparietal sulcus. Exploratory analyses revealed that this relationship was putatively driven by an increase in negative connectivity strength of the structure. This resting-state connectivity finding fits previous task based activation studies that have shown that this area responds to manipulations of working memory load.

Keywords

Working memory Resting-state fMRI Connectome Intraparietal sulcus Working memory capacity, cognitive ability 

Notes

Compliance with ethical standards

Funding

This work was supported by two grants from the German Research Foundation (DFG) awarded to Christian Montag (MO-2363/2–1 and MO-2363/3–1).

Conflict of interest

All authors declare no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Sebastian Markett
    • 1
    • 2
  • Martin Reuter
    • 1
    • 2
  • Behrend Heeren
    • 3
  • Bernd Lachmann
    • 4
  • Bernd Weber
    • 2
    • 4
    • 5
  • Christian Montag
    • 6
    • 7
  1. 1.Department of PsychologyUniversity of BonnBonnGermany
  2. 2.Center for Economics and NeuroscienceUniversity of BonnBonnGermany
  3. 3.Institute for Numerical SimulationUniversity of BonnBonnGermany
  4. 4.Department of EpileptologyUniversity of BonnBonnGermany
  5. 5.Department of NeuroCognition, Life & Brain CenterUniversity of BonnBonnGermany
  6. 6.Institute of Psychology and EducationUlm UniversityUlmGermany
  7. 7.Key Laboratory for NeuroInformationUniversity of Electronic Science and Technology of ChinaChengduChina

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