Imaging the up’s and down’s of emotion regulation in lifetime depression

  • Sina Radke
  • Felix Hoffstaedter
  • Leonie Löffler
  • Lydia Kogler
  • Frank Schneider
  • Jens Blechert
  • Birgit Derntl
Original Research

Abstract

Reappraisal is a particularly effective strategy for influencing emotional experiences, specifically for reducing the impact of negative stimuli. Although depression has repeatedly been linked to dysfunctional behavioral and neural emotion regulation, prefrontal and amygdala engagement seems to vary with clinical characteristics and the specific regulation strategy used. Whereas previous neuroimaging research has focused on down-regulating reactions to emotionally evocative scenes, the current study compared up- and down-regulation in response to angry facial expressions in patients with depression and healthy individuals. During the initial viewing of faces, patients with depression showed hypoactivation particularly in areas implicated in emotion generation, i.e., amygdala, insula and putamen. In contrast, up-regulating negative emotions yielded stronger recruitment of core face processing areas and posterior medial frontal cortex in patients than in controls. However, group differences did not extend to resting-state functional connectivity. Recurrent depression was inversely associated with amygdala activation specifically during down-regulation, but differences in medication status may limit the current findings. Despite a pattern of reduced neural emotional reactivity in mainly medicated patients, their ‘successful’ recruitment of the regulation network for up-regulation might point toward an effective use of reappraisal when increasing negative emotions. Future studies need to address how patients might benefit from transferring this ability to adaptive goals, such as improving interpersonal emotion regulation.

Keywords

Depression Emotion regulation Facial expression fMRI Reappraisal 

Supplementary material

11682_2017_9682_MOESM1_ESM.docx (20 kb)
Supplementary Table S1(DOCX 19 kb)

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Department of Psychiatry, Psychotherapy and Psychosomatics, Medical FacultyRWTH Aachen UniversityAachenGermany
  2. 2.Jülich Aachen Research Alliance (JARA) - BRAIN Institute Brain Structure-Function Relationships: Decoding the Human Brain at systemic levelsForschungszentrum Jülich GmbH and RWTH Aachen UniversityJülichGermany
  3. 3.Institute of Neuroscience and Medicine (INM-1)Research Centre JülichJülichGermany
  4. 4.Institute of Clinical Neuroscience and Medical PsychologyHeinrich Heine University DüsseldorfDüsseldorfGermany
  5. 5.Department of Psychiatry and Psychotherapy, Medical SchoolUniversity of TübingenTübingenGermany
  6. 6.Department of PsychologyUniversity of SalzburgSalzburgAustria
  7. 7.Centre for Cognitive NeuroscienceUniversity of SalzburgSalzburgAustria
  8. 8.Werner Reichardt Center for Integrative NeuroscienceUniversity of TübingenTübingenGermany
  9. 9.LEAD Graduate SchoolUniversity of TübingenTübingenGermany

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