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Brain Imaging and Behavior

, Volume 11, Issue 4, pp 954–963 | Cite as

Short-term memory deficits correlate with hippocampal-thalamic functional connectivity alterations following acute sleep restriction

  • Li Chengyang
  • Huang Daqing
  • Qi Jianlin
  • Chang Haisheng
  • Meng Qingqing
  • Wang Jin
  • Liu Jiajia
  • Ye Enmao
  • Shao Yongcong
  • Zhang Xi
Original Research

Abstract

Acute sleep restriction heavily influences cognitive function, affecting executive processes such as attention, response inhibition, and memory. Previous neuroimaging studies have suggested a link between hippocampal activity and short-term memory function. However, the specific contribution of the hippocampus to the decline of short-term memory following sleep restriction has yet to be established. In the current study, we utilized resting-state functional magnetic resonance imaging (fMRI) to examine the association between hippocampal functional connectivity (FC) and the decline of short-term memory following total sleep deprivation (TSD). Twenty healthy adult males aged 20.9 ± 2.3 years (age range, 18–24 years) were enrolled in a within-subject crossover study. Short-term memory and FC were assessed using a Delay-matching short-term memory test and a resting-state fMRI scan before and after TSD. Seed-based correlation analysis was performed using fMRI data for the left and right hippocampus to identify differences in hippocampal FC following TSD. Subjects demonstrated reduced alertness and a decline in short-term memory performance following TSD. Moreover, fMRI analysis identified reduced hippocampal FC with the superior frontal gyrus (SFG), temporal regions, and supplementary motor area. In addition, an increase in FC between the hippocampus and bilateral thalamus was observed, the extent of which correlated with short-term memory performance following TSD. Our findings indicate that the disruption of hippocampal–cortical connectivity is linked to the decline in short-term memory observed after acute sleep restriction. Such results provide further evidence that support the cognitive impairment model of sleep deprivation.

Keywords

Sleep deprivation Hippocampus Thalamus Memory Functional connectivity 

Notes

Compliance with ethical standards

Funding

This work was supported by the National Military Science Foundation of China, No. AWS14J011.

Conflict of interest

None.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Li Chengyang
    • 1
  • Huang Daqing
    • 2
  • Qi Jianlin
    • 3
  • Chang Haisheng
    • 4
  • Meng Qingqing
    • 5
  • Wang Jin
    • 3
  • Liu Jiajia
    • 3
  • Ye Enmao
    • 6
  • Shao Yongcong
    • 6
  • Zhang Xi
    • 5
  1. 1.Department of CardiologyThe People’s Hospital of Liaoning ProvinceShenyangPeople’s Republic of China
  2. 2.Center of Psychological Quality EducationBeijing Union UniversityBeijingPeople’s Republic of China
  3. 3.Department of Clinical Psychology PLAAir Force General HospitalBeijingPeople’s Republic of China
  4. 4.Chinese People’s Armed Police ForcesThe Third Hospital of Beijing Municipal CorpsBeijingPeople’s Republic of China
  5. 5.Department of Geriatric Neurology, Sleep Medicine Research CenterChinese PLA General Hospital, The General Hospital of the People’s Liberation ArmyBeijingPeople’s Republic of China
  6. 6.Cognitive and Mental Health Research CenterBeijing Institute of Basic Medical ScienceBeijingPeople’s Republic of China

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