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Brain Imaging and Behavior

, Volume 11, Issue 4, pp 925–935 | Cite as

Overweight adolescents’ brain response to sweetened beverages mirrors addiction pathways

  • Sarah W. Feldstein Ewing
  • Eric D. Claus
  • Karen A. Hudson
  • Francesca M. Filbey
  • Elizabeth Yakes Jimenez
  • Krista M. Lisdahl
  • Alberta S. Kong
Original Research

Abstract

Many adolescents struggle with overweight/obesity, which exponentially increases in the transition to adulthood. Overweight/obesity places youth at risk for serious health conditions, including type 2 diabetes. In adults, neural substrates implicated in addiction (e.g., orbitofrontal cortex (OFC), striatum, amygdala, and ventral tegmental area) have been found to be relevant to risk for overweight/obesity. In this study, we examined three hypotheses to disentangle the potential overlap between addiction and overweight/obesity processing by examining (1) brain response to high vs. low calorie beverages, (2) the strength of correspondence between biometrics, including body mass index (BMI) and insulin resistance, and brain response and (3) the relationship between a measure of food addiction and brain response using an established fMRI gustatory cue exposure task with a sample of overweight/obese youth (M age = 16.46; M BMI = 33.1). Greater BOLD response was observed across the OFC, inferior frontal gyrus (IFG), nucleus accumbens, right amygdala, and additional frontoparietal and temporal regions in neural processing of high vs. low calorie beverages. Further, BMI scores positively correlated with BOLD activation in the high calorie > low calorie contrast in the right postcentral gyrus and central operculum. Insulin resistance positively correlated with BOLD activation across the bilateral middle/superior temporal gyrus, left OFC, and superior parietal lobe. No relationships were observed between measures of food addiction and brain response. These findings support the activation of parallel addiction-related neural pathways in adolescents’ high calorie processing, while also suggesting the importance of refining conceptual and neurocognitive models to fit this developmental period.

Keywords

Adolescents Overweight/obesity Cue exposure fMRI Addiction 

Notes

Acknowledgments

The authors would like to thank Dustin Truitt for his contribution to this project.

Sources of support

This research was supported by the University of New Mexico Pediatric Research Allocations Committee, the La Tierra Sagrada Society, and the Mind Research Network.

Compliance with ethical standards

Financial disclosures

The authors declare that they have no competing financial or other conflicts of interest relating to the data included in the manuscript.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Sarah W. Feldstein Ewing
    • 1
  • Eric D. Claus
    • 2
  • Karen A. Hudson
    • 1
  • Francesca M. Filbey
    • 3
  • Elizabeth Yakes Jimenez
    • 4
  • Krista M. Lisdahl
    • 5
  • Alberta S. Kong
    • 6
  1. 1.Oregon Health & Science UniversityPortlandUSA
  2. 2.The Mind Research NetworkAlbuquerqueUSA
  3. 3.Center for BrainHealth, School of Behavioral and Brain SciencesThe University of Texas at DallasDallasUSA
  4. 4.Departments of Individual, Family and Community Education and Family and Community Medicine, University of New Mexico1 University of New MexicoAlbuquerqueUSA
  5. 5.Department of PsychologyUniversity of Wisconsin-MilwaukeeMilwaukeeUSA
  6. 6.Department of Pediatrics, Division of Adolescent Medicine and Department of Family and Community MedicineUniversity of New MexicoAlbuquerqueUSA

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