Brain Imaging and Behavior

, Volume 11, Issue 3, pp 632–639

Cognitive reserve moderates the relationship between neuropsychological performance and white matter fiber bundle length in healthy older adults

  • Laurie M. Baker
  • David H. Laidlaw
  • Ryan Cabeen
  • Erbil Akbudak
  • Thomas E. Conturo
  • Stephen Correia
  • David F. Tate
  • Jodi M. Heaps-Woodruff
  • Matthew R. Brier
  • Jacob Bolzenius
  • Lauren E. Salminen
  • Elizabeth M. Lane
  • Amanda R. McMichael
  • Robert H. Paul
Original Research

DOI: 10.1007/s11682-016-9540-7

Cite this article as:
Baker, L.M., Laidlaw, D.H., Cabeen, R. et al. Brain Imaging and Behavior (2017) 11: 632. doi:10.1007/s11682-016-9540-7

Abstract

Recent work using novel neuroimaging methods has revealed shorter white matter fiber bundle length (FBL) in older compared to younger adults. Shorter FBL also corresponds to poorer performance on cognitive measures sensitive to advanced age. However, it is unclear if individual factors such as cognitive reserve (CR) effectively moderate the relationship between FBL and cognitive performance. This study examined CR as a potential moderator of cognitive performance and brain integrity as defined by FBL. Sixty-three healthy adults underwent neuropsychological evaluation and 3T brain magnetic resonance imaging. Cognitive performance was measured using the Repeatable Battery of Assessment of Neuropsychological Status (RBANS). FBL was quantified from tractography tracings of white matter fiber bundles, derived from the diffusion tensor imaging. CR was determined by estimated premorbid IQ. Analyses revealed that lower scores on the RBANS were associated with shorter whole brain FBL (p = 0.04) and lower CR (p = 0.01) CR moderated the relationship between whole brain FBL and RBANS score (p < 0.01). Tract-specific analyses revealed that CR also moderated the association between FBL in the hippocampal segment of the cingulum and RBANS performance (p = 0.03). These results demonstrate that lower cognitive performance on the RBANS is more common with low CR and short FBL. On the contrary, when individuals have high CR, the relationship between FBL and cognitive performance is attenuated. Overall, CR protects older adults against lower cognitive performance despite age-associated reductions in FBL.

Keywords

Cognition Aging Neuropsychological assessment Diffusion tensor imaging RBANS 

Funding information

Funder NameGrant NumberFunding Note
National Institute of Neurological Disorders and Stroke
  • R01NS052470
  • R01NS039538
National Institute of Mental Health
  • R21MH090494
  • R21MH105822

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Laurie M. Baker
    • 1
  • David H. Laidlaw
    • 2
  • Ryan Cabeen
    • 2
  • Erbil Akbudak
    • 3
  • Thomas E. Conturo
    • 3
  • Stephen Correia
    • 4
  • David F. Tate
    • 5
  • Jodi M. Heaps-Woodruff
    • 5
  • Matthew R. Brier
    • 6
  • Jacob Bolzenius
    • 5
  • Lauren E. Salminen
    • 1
  • Elizabeth M. Lane
    • 7
  • Amanda R. McMichael
    • 3
  • Robert H. Paul
    • 1
    • 5
  1. 1.Department of Psychological SciencesUniversity of Missouri – Saint LouisSaint LouisUSA
  2. 2.Computer Science DepartmentBrown UniversityProvidenceUSA
  3. 3.Mallinckrodt Institute of RadiologyWashington University School of MedicineSt. LouisUSA
  4. 4.Division of Biology and MedicineBrown Medical SchoolProvidenceUSA
  5. 5.Missouri Institute of Mental HealthSt. LouisUSA
  6. 6.Department of NeurologyWashington University School of MedicineSt. LouisUSA
  7. 7.Department of NeurologyVanderbilt University Medical CenterNashvilleUSA

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