Brain Imaging and Behavior

, Volume 10, Issue 4, pp 1068–1079 | Cite as

Structural covariance mapping delineates medial and medio-lateral temporal networks in déjà vu

  • Daniel Joel Shaw
  • Radek Mareček
  • Milan Brázdil
Original Research

Abstract

Déjà vu (DV) is an eerie phenomenon experienced frequently as an aura of temporal lobe epilepsy, but also reported commonly by healthy individuals. The former pathological manifestation appears to result from aberrant neural activity among brain structures within the medial temporal lobes. Recent studies also implicate medial temporal brain structures in the non-pathological experience of DV, but as one element of a diffuse neuroanatomical correlate; it remains to be seen if neural activity among the medial temporal lobes also underlies this benign manifestation. The present study set out to investigate this. Due to its unpredictable and infrequent occurrence, however, non-pathological DV does not lend itself easily to functional neuroimaging. Instead, we draw on research showing that brain structure covaries among regions that interact frequently as nodes of functional networks. Specifically, we assessed whether grey-matter covariance among structures implicated in non-pathological DV differs according to the frequency with which the phenomenon is experienced. This revealed two diverging patterns of structural covariation: Among the first, comprised primarily of medial temporal structures and the caudate, grey-matter volume becomes more positively correlated with higher frequency of DV experience. The second pattern encompasses medial and lateral temporal structures, among which greater DV frequency is associated with more negatively correlated grey matter. Using a meta-analytic method of co-activation mapping, we demonstrate a higher probability of functional interactions among brain structures constituting the former pattern, particularly during memory-related processes. Our findings suggest that altered neural signalling within memory-related medial temporal brain structures underlies both pathological and non-pathological DV.

Keywords

Déjà vu Memory Grey matter Structural co-variance Meta-analytic connectivity modelling 

Supplementary material

11682_2015_9471_Fig4_ESM.jpg (215 kb)
Supplementary Figure 1

Meta-analytic co-activation matrix. Meta-analytic connectivity modelling (MACM) was employed to compare the probability of co-activation between cells comprising the positive and negative pattern of structural covariance, and perform a behavioral characterisation of each pattern. The matrix presents the standardized probability of co-activation among each VOI (rows) when each other VOI served as a seed (columns; see Multi-analytic Connectivity Modelling). For abbreviations see Table 1. (JPEG 215 kb)

11682_2015_9471_MOESM_ESM.tif (12 mb)
High resolution (TIFF 12299 kb)

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Behavioral and Social Neuroscience Research Group, CEITEC - Central European Institute of TechnologyMasaryk UniversityBrnoCzech Republic
  2. 2.First Department of Neurology, Faculty of MedicineMasaryk University and St. Anne’s Faculty HospitalBrnoCzech Republic

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