Brain Imaging and Behavior

, Volume 10, Issue 4, pp 960–969 | Cite as

Action observation and imitation in autism spectrum disorders: an ALE meta-analysis of fMRI studies

Original Research

Abstract

Previous studies have shown that the mirror neuron system (MNS) plays an important role in action understanding. However, whether and how the MNS activity is different in individuals with autism spectrum disorders (ASD) and typically developed (TD) individuals are still unclear. The current study used activation likelihood estimation to conduct a meta-analysis of functional magnetic resonance imaging studies that investigated action observation and imitation in ASD and TD individuals. Thirteen studies were selected, and the contrasts focused on the brain effects in ASD and TD participants and the differences between the two groups. The results showed that compared with TD individuals, ASD individuals exhibited stronger effects in the anterior inferior parietal lobule, a part of the putative human MNS. In addition, the ASD group demonstrated altered effects in the occipital cortex, dorsolateral prefrontal cortex, cingulate cortex, and insula. These results suggest that ASD individuals demonstrate dysfunction of the MNS during action observation and imitation. Furthermore, brain regions involved in visual processing, executive function, and social cognitive function might also show dysfunction during action task performance.

Keywords

Autism spectrum disorders The mirror neuron system Action observation Action imitation Activation likelihood estimation Functional magnetic resonance imaging 

Supplementary material

11682_2015_9456_Fig2_ESM.gif (34 kb)
Supplementary Figure 1

The paper selection procedure of the current meta-analysis. (GIF 33 kb)

11682_2015_9456_MOESM1_ESM.tiff (5.2 mb)
(TIFF 5313 kb)

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.ARC Center of Excellence in Cognition and its Disorders, Department of Cognitive SciencesMacquarie UniversitySydneyAustralia

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