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Brain Imaging and Behavior

, Volume 10, Issue 4, pp 984–994 | Cite as

Morphological alterations in amygdalo-hippocampal substructures in narcolepsy patients with cataplexy

  • Hosung Kim
  • Sooyeon Suh
  • Eun Yeon JooEmail author
  • Seung Bong HongEmail author
Original Research

Abstract

Although the role of hypocretin-mediated amygdalo-hippocampal dysfunction is hypothesized to be linked with narcolepsy, there have been no human MRI studies investigating the relationship between their regional volume and key symptoms of narcolepsy. To investigate the morphological changes of amygdalo-hippocampus and its relationship with clinical features in patients with narcolepsy, point-wise morphometry that allowed for measuring the regional volumes of amygdalo-hippocampus on T1-weighted MRI was applied. Participants were 33 drug-naïve patients and 35 age-/gender-matched controls (mean ± SD: 27 ± 6 years). We compared hippocampal and amygdalar subfields volumes between patients and controls and correlated between volume and clinical and neuropsychological features in patients. Bilateral hippocampal atrophy (183 vertices) was identified mainly located within the CA1 subfield (FDR < 0.05). Significant amygdalar volume reduction was found in the areas of the centromedial (102 vertices) and laterobasal nuclear groups (LB, 35 vertices). There was no volume increase in patients relative to controls (FDR >0.2). After controlling depressive mood, sleep quality, age, and gender, hippocampal CA1 atrophy and amygdalar centromedial atrophy were associated with longer duration of daytime sleepiness and shorter mean REM sleep latency (|r| >0.44, p < 0.01). The amygdalar centromedial atrophy was associated with longer duration of cataplexy (|r| >0.47, p < 0.005). Subfields atrophy of amygdalo-hippocampus in untreated patients with narcolepsy that was found relative to controls suggests that CA1 of the hippocampus and centromedial area of amygdala are closely related to the severity of narcolepsy and play a crucial role in the circuitry of cataplexy.

Keywords

Narcolepsy Amygdale Hippocampus Surface analysis MRI volumetry 

Notes

Funding

This study was funded by Basic Science Research Program through the National Research Foundation of Korea of the Ministry of Science, ICT & Future Planning, Republic of Korea (No. 2014R1A1A3049510) and by Samsung Biomedical Research Institute grant (#OTX0002111).

Conflict of interest

All authors (Kim H, Suh S, Joo EY, and Hong SB) declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Neurology, Neuroscience Center, Samsung Medical Center, Samsung Biomedical Research InstituteSungkyunkwan University School of MedicineSeoulKorea
  2. 2.Department of Radiology and Biomedical ImagingUniversity of California, San FranciscoSan FranciscoUSA
  3. 3.Department of PsychologySungshin Women’s UniversitySeoulKorea
  4. 4.Department of PsychiatryStanford UniversityRedwood CityUSA

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