Brain Imaging and Behavior

, Volume 10, Issue 3, pp 719–729 | Cite as

Abnormal prefrontal cortex resting state functional connectivity and severity of internet gaming disorder

  • Chenwang JinEmail author
  • Ting Zhang
  • Chenxi Cai
  • Yanzhi Bi
  • Yangding Li
  • Dahua Yu
  • Ming Zhang
  • Kai YuanEmail author
Original Research


Internet Gaming Disorder (IGD) among adolescents has become an important public concern and gained more and more attention internationally. Recent studies focused on IGD and revealed brain abnormalities in the IGD group, especially the prefrontal cortex (PFC). However, the role of PFC-striatal circuits in pathology of IGD remains unknown. Twenty-five adolescents with IGD and 21 age- and gender-matched healthy controls were recruited in our study. Voxel-based morphometric (VBM) and functional connectivity analysis were employed to investigate the abnormal structural and resting-state properties of several frontal regions in individuals with online gaming addiction. Relative to healthy comparison subjects, IGD subjects showed significant decreased gray matter volume in PFC regions including the bilateral dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC), anterior cingulate cortex (ACC) and the right supplementary motor area (SMA) after controlling for age and gender effects. We chose these regions as the seeding areas for the resting-state analysis and found that IGD subjects showed decreased functional connectivity between several cortical regions and our seeds, including the insula, and temporal and occipital cortices. Moreover, significant decreased functional connectivity between some important subcortical regions, i.e., dorsal striatum, pallidum, and thalamus, and our seeds were found in the IGD group and some of those changes were associated with the severity of IGD. Our results revealed the involvement of several PFC regions and related PFC-striatal circuits in the process of IGD and suggested IGD may share similar neural mechanisms with substance dependence at the circuit level.


Gray matter volume Functional connectivity Internet gaming disorder Prefrontal cortex-striatal circuits 



This paper is supported by the Project for the National Key Basic Research and Development Program (973) under Grant nos. 2014CB543203, 2011CB707700, 2012CB518501, the National Natural Science Foundation of China under Grant nos. 81401478, 81401488, 81227901, 81271644, 81271546, 81101036, 81101108, 31200837, 81301281, the Natural Science Basic Research Plan in Shaanxi Province of China under Grant no. 2014JQ4118, and the Fundamental Research Funds for the Central Universities under the Grant nos. 8002-72125760, 8002-72135767, 8002-72145760, the Natural Science Foundation of Inner Mongolia under Grant no. 2012MS0908. General Financial Grant the China Post- doctoral Science Foundation under Grant no. 2014 M552416. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Medical Imaging, the First Affiliated Hospital of Medical CollegeXi’an Jiaotong UniversityXi’anChina
  2. 2.College of TourismGuilin Technology of UniversityGuilinChina
  3. 3.School of Humanities and Social SciencesXi’an Jiaotong UniversityXi’anChina
  4. 4.Life Sciences Research Center, School of Life Sciences and TechnologyXidian UniversityXi’anChina
  5. 5.Information Processing Laboratory, School of Information EngineeringInner Mongolia University of Science and TechnologyBaotouChina

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