Brain Imaging and Behavior

, Volume 8, Issue 3, pp 403–406 | Cite as

A pilot study examining functional brain activity 6 months after memory retraining in MS: the MEMREHAB trial

  • Ekaterina Dobryakova
  • Glenn R. Wylie
  • John DeLuca
  • Nancy D. ChiaravallotiEmail author
Neuroimaging and Rehabilitation SPECIAL ISSUE


Cognitive impairment in individuals with multiple sclerosis (MS) is now well recognized. One of the most common cognitive deficits is found in memory functioning, largely due to impaired acquisition. We examined functional brain activity 6 months after memory retraining in individuals with MS. The current report presents long term follow-up results from a randomized clinical trial on a memory rehabilitation protocol known as the modified Story Memory Technique. Behavioral memory performance and brain activity of all participants were evaluated at baseline, immediately after treatment, and 6 months after treatment. Results revealed that previously observed increases in patterns of cerebral activation during learning immediately after memory training were maintained 6 months post training.


fMRI Memory rehabilitation Clinical trial 



The authors would like to acknowledge grant support from the National Institute of Health (NCMRR) to N. D. Chiaravalloti (R01 HD045798S, R01 HD045798) and the Kessler Foundation. The contents of this article were also developed under the NIDRR grant # H133P090009 to N.D. Chiaravalloti. However, these contents do not necessarily represent the policy of the Department of Education, and endorsement by the Federal Government should not be assumed.

Conflict of Interest

Ekaterina Dobryakova, Glenn R. Wylie, John DeLuca, and Nancy Chiaravalloti report no conflicts of interest.

Informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, and the applicable revisions at the time of the investigation. Informed consent was obtained from all patients for being included in the study.

Supplementary material

11682_2014_9309_MOESM1_ESM.doc (38 kb)
ESM 1 (DOC 38 kb)


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Ekaterina Dobryakova
    • 1
    • 2
  • Glenn R. Wylie
    • 1
    • 2
    • 3
  • John DeLuca
    • 1
    • 2
    • 4
  • Nancy D. Chiaravalloti
    • 1
    • 2
    Email author
  1. 1.Kessler Foundation Research CenterWest OrangeUSA
  2. 2.Department of Physical Medicine and RehabilitationRutgers New Jersey Medical SchoolNewarkUSA
  3. 3.Department of Veteran’s AffairsWar Related Illness & Injury Study CenterEast OrangeUSA
  4. 4.Department of Neurology and NeurosciencesRutgers New Jersey Medical SchoolNewarkUSA

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