Brain Imaging and Behavior

, Volume 8, Issue 3, pp 403–406

A pilot study examining functional brain activity 6 months after memory retraining in MS: the MEMREHAB trial

  • Ekaterina Dobryakova
  • Glenn R. Wylie
  • John DeLuca
  • Nancy D. Chiaravalloti
Neuroimaging and Rehabilitation SPECIAL ISSUE

Abstract

Cognitive impairment in individuals with multiple sclerosis (MS) is now well recognized. One of the most common cognitive deficits is found in memory functioning, largely due to impaired acquisition. We examined functional brain activity 6 months after memory retraining in individuals with MS. The current report presents long term follow-up results from a randomized clinical trial on a memory rehabilitation protocol known as the modified Story Memory Technique. Behavioral memory performance and brain activity of all participants were evaluated at baseline, immediately after treatment, and 6 months after treatment. Results revealed that previously observed increases in patterns of cerebral activation during learning immediately after memory training were maintained 6 months post training.

Keywords

fMRI Memory rehabilitation Clinical trial 

Supplementary material

11682_2014_9309_MOESM1_ESM.doc (38 kb)
ESM 1(DOC 38 kb)

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Ekaterina Dobryakova
    • 1
    • 2
  • Glenn R. Wylie
    • 1
    • 2
    • 3
  • John DeLuca
    • 1
    • 2
    • 4
  • Nancy D. Chiaravalloti
    • 1
    • 2
  1. 1.Kessler Foundation Research CenterWest OrangeUSA
  2. 2.Department of Physical Medicine and RehabilitationRutgers New Jersey Medical SchoolNewarkUSA
  3. 3.Department of Veteran’s AffairsWar Related Illness & Injury Study CenterEast OrangeUSA
  4. 4.Department of Neurology and NeurosciencesRutgers New Jersey Medical SchoolNewarkUSA

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