Reliability of negative BOLD in ipsilateral sensorimotor areas during unimanual task activity
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Research using functional magnetic resonance imaging has for numerous years now reported the existence of a negative blood oxygenation level dependent (BOLD) response. Based on accumulating evidence, this negative BOLD signal appears to represent an active inhibition of cortical areas in which it is found during task activity. This particularly important with respect to motor function given that it is fairly well-established that, in younger adults, the ipsilateral sensorimotor cortex exhibits negative BOLD during unimanual movements in fMRI. This interhemispheric suppression of cortical activity may have useful implications for our understanding of both basic motor function and rehabilitation of injury or disease. However, to date, we are aware of no study that has tested the reliability of evoked negative BOLD in ipsilateral sensorimotor cortex in individuals across sessions. The current study employs a unimanual finger opposition task previously shown to evoke negative BOLD in ipsilateral sensorimotor cortex across three sessions. Reliability metrics across sessions indicates that both the magnitude and location of ipsilateral sensorimotor negative BOLD response is relatively stable over each of the three sessions. Moreover, the volume of negative BOLD in ipsilateral cortex was highly correlated with volume of positive BOLD activity in the contralateral primary motor cortex. These findings show that the negative BOLD signal can be reliably evoked in unimanual task paradigms, and that the signal dynamic could represent an active suppression of the ipsilateral sensorimotor cortex originating from the contralateral motor areas.
KeywordsfMRI Ipsilateral inhibition Negative BOLD Reliability Sensorimotor activity
The contents do not represent the views of the Department of Veterans Affairs or the United States Government. This work was supported by a Department of Veteran Affairs (VA) Rehabilitation R&D Center of Excellence #F2182C, Career Development Award Level-2 (KMM) and Senior Research Career Scientist (BC: #B6364L) awards.
Conflict of interest
Keith M. McGregor, Atchar Sudhyadhom, Joe Nocera, Ari Seff, Bruce Crosson, and Andrew J. Butler report no conflicts of interest.
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, and the applicable revisions at the time of the investigation. Informed consent was obtained from all patients for being included in the study.
- Berlucchi, G. (1990). Commisurotomy studies in animals. In F. Boller & J. Grafman (Eds.), Handbook of neurophysiology. Vol. 4 (pp. 9–47). Amsterdam: Elsevier.Google Scholar
- Bright, M. G., Bianciardi, M., de Zwart, J. A., Murphy, K., Duyn, J. H., (2014) Early anti-correlated BOLD signal changes of physiologic origin. Neuroimage, 15(87), 287–96. Google Scholar
- Diekhoff, S., Uludağ, K., Sparing, R., Tittgemeyer, M., Cavuşoğlu, M., von Cramon, D, Y., et al. (2011) Functional localization in the human brain: Gradient-Echo, Spin-Echo, and arterial spin-labeling fMRI compared with neuronavigated TMS. Hum Brain Mapp, 32(3), 341–57. Google Scholar
- Fesl, G., Braun, B., Rau, S., Wiesmann, M., Ruge, M., Bruhns, P., et al. (2008). Is the center of mass (COM) a reliable parameter for the localization of brain function in fMRI? Eur Radiol, 18(5), 1031–7.Google Scholar
- Jaccard, P. (1901). Étude comparative de la distribution florale dans une portion des Alpes et des Jura. Bulletin de la Société Vaudoise des Sciences Naturelles, 37, 547–579.Google Scholar
- Kobayashi, M., Hutchinson, S., Schlaug, G., Pascual-Leone, A. (2003). Ipsilateral motor cortex activation on functional magnetic resonance imaging during unilateral hand movements is related to interhemispheric interactions. Neuroimage, 20(4), 2259–2270.Google Scholar
- Manson, S. C., Wegner, C., Filippi, M., Barkhof, F., Beckmann, C., Ciccarelli, O., et al. (2008). Impairment of movement-associated brain deactivation in multiple sclerosis: further evidence for a functional pathology of interhemispheric neuronal inhibition. Experimental Brain Research, 187, 25–31.CrossRefPubMedCentralPubMedGoogle Scholar
- Mayston, M. J., Harrison, L. M., Quinton, R., Stephens, J. A., Krams, M., Bouloux, P. M. (1997). Mirror movements in X-linked Kallmann’s syndrome. I. A neurophysiological study. Brain, 120(Pt 7), 1199–1216.Google Scholar
- Northoff, G., Walter, M., Schulte, R. F., Beck, J., Dydak, U., Henning, A., … & Boesiger, P. (2007). GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI. Nature Neuroscience, 10(12), 1515–1517.Google Scholar
- Portney, L. G., & Watkins, M. P. (1993). Chapter 26: Statistical measures of reliability. Foundation of clinical research: Applications to practice. Norwich: Appleton and Lange.Google Scholar
- Real, R. (1999). Tables of significant values of Jaccard’s index of similarity. Miscellaneous Zoologica, 22(1), 29–40.Google Scholar
- Salthouse, T. A. (1996). The processing-speed theory of adult age differences in cognition. Psychol Rev, 103(3), 403–28.Google Scholar
- Sattler, V., Dickler, M., Michaud, M., Meunier, S., Simonetta-Moreau, M. (2013). Does abnormal interhemispheric inhibition play a role in mirror dystonia? Movement Disorders.Google Scholar
- Sherrington, C. S. (1932). Nobel Prize Lecture. http://www.nobelprize.org/nobel_prizes/medicine/laureates/1932/press.html. Accessed 28 April 2014.
- Stagg, C. J., Bestmann, S., Constantinescu, A. O., Moreno, L. M., Allman, C., Mekle, R., et al. (2011) Relationship between physiological measures of excitability and levels of glutamate and GABA in the human motor cortex. Journal of Physiology, 589(Pt 23), 5845–55.Google Scholar
- Yousry, T. A., Schmid, U. D., Alkadhi, H., Schmidt, D., Peraud, A., Buettner, A., et al. (1997). Localization of the motor hand area to a knob on the precentral gyrus. A new landmark. Brain, 120(Pt 1), 141–57.Google Scholar
- Zeharia, N., Hertz, U., Flash, T., & Amedi, A. (2012). Negative blood oxygenation level dependent homunculus and somatotopic information in primary motor cortex and supplementary motor area. Proceedings of the National Academy of Sciences of the United States of America, 109, 18565–18570.CrossRefPubMedCentralPubMedGoogle Scholar