Brain Imaging and Behavior

, Volume 8, Issue 2, pp 251–261 | Cite as

Imaging markers of structural and functional brain changes that precede cognitive symptoms in risk for Alzheimer’s disease

  • Alison BurggrenEmail author
  • Jesse Brown
SI: Genetic Neuroimaging in Aging and Age-Related Diseases


Neuroimaging has rapidly advanced investigations into dysfunction both within and emanating from the hippocampus in early Alzheimer’s disease . Focusing on prodromal subjects, we will discuss structural changes to hippocampal subregions, alterations to functional activity both within the hippocampus and elsewhere in the cortex, as well as changes to structural white matter connectivity and changes to functionally correlated patterns during memory performance. We present ample evidence that asymptomatic subjects demonstrate substantial identifiable brain changes before the onset of cognitive decline, but suggest there is significant work yet to be accomplished before applying these findings to individual patients.


Medial temporal lobe Hippocampus Magnetic resonance imaging Diffusion tensor imaging Functional magnetic resonance imaging APOE 



The authors thank Ms. Natacha Donoghue and Ms. Jacqueline Martinez for help in subject recruitment, data management, and study coordination.

Financial disclosure

The primary investigator has no financial interests that could conflict with the current study.

Funding support

Supported by NIH grants P01-AG025831, R01-AG13308, P50-AG 16570, MH/AG58156, MH52453; AG10123; M01-RR00865, General Clinical Research Centers Program, the Fran and Ray Stark Foundation Fund for Alzheimer’s Disease Research; the Larry L. Hillblom Foundation. No company provided support of any kind for this study.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Center for Cognitive Neurosciences, Semel Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral SciencesUniversity of CaliforniaLos AngelesUSA
  2. 2.Memory and Aging Center, Department of NeurologyUniversity of California, San FranciscoSan FranciscoUSA
  3. 3.Semel Neuropsychiatric Institute 17–369University of CaliforniaLos AngelesUSA

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