Brain Imaging and Behavior

, Volume 7, Issue 4, pp 453–459

Chemotherapy-related cognitive dysfunction: current animal studies and future directions

  • R. Seigers
  • S. B. Schagen
  • O. Van Tellingen
  • J. Dietrich
SI: Neuroimaging Studies of Cancer and Cancer Treatment

Abstract

Cognitive impairment is a potential long-term side effect of adjuvant chemotherapy that can have a major impact on the quality of life of cancer survivors. There is a growing number of preclinical studies addressing this issue, thereby extending our knowledge of the mechanisms underlying chemotherapy-induced neurotoxicity. In this review, we will summarize the recent advances and important findings presented in these studies. Emerging challenges, such as the development of neuroprotective strategies, and the role of the blood-brain barrier on cognitive impairment will be described and future directions in this field of investigation will be outlined.

Keywords

Review Animal Chemotherapy Cognition Impairment Cytostatic 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • R. Seigers
    • 1
  • S. B. Schagen
    • 1
  • O. Van Tellingen
    • 2
  • J. Dietrich
    • 3
  1. 1.Department of Psychosocial Research and EpidemiologyThe Netherlands Cancer InstituteAmsterdamThe Netherlands
  2. 2.Division of Molecular BiologyThe Netherlands Cancer InstituteAmsterdamThe Netherlands
  3. 3.Department of Neurology, Division of Neuro-Oncology, Massachusetts General Hospital Cancer CenterHarvard Medical SchoolBostonUSA

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