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Brain Imaging and Behavior

, Volume 4, Issue 1, pp 35–45 | Cite as

Basal Ganglia MR Relaxometry in Obsessive-Compulsive Disorder: T2 Depends Upon Age of Symptom Onset

  • Stephen Correia
  • Emily Hubbard
  • Jason Hassenstab
  • Agustin Yip
  • Josef Vymazal
  • Vit Herynek
  • Jay Giedd
  • Dennis L. Murphy
  • Benjamin D. Greenberg
Article

Abstract

Dysfunction in circuits linking frontal cortex and basal ganglia (BG) is strongly implicated in obsessive-compulsive disorder (OCD). On MRI studies, neuropsychiatric disorders with known BG pathology have abnormally short T2 relaxation values (a putative biomarker of elevated iron) in this region. We asked if BG T2 values are abnormal in OCD. We measured volume and T2 and T1 relaxation rates in BG of 32 adults with OCD and 33 matched controls. There were no group differences in volume or T1 values in caudate, putamen, or globus pallidus (GP). The OCD group had lower T2 values (suggesting higher iron content) in the right GP, with a trend in the same direction for the left GP. This effect was driven by patients whose OCD symptoms began from around adolescence to early adulthood. The results suggest a possible relationship between age of OCD onset and iron deposition in the basal ganglia.

Keywords

Obsessive-compulsive disorder Basal ganglia Age of onset Iron Magnetic Resonance Imaging 

Notes

Acknowledgments

We wish to thank David Strong, Ph.D. for his contribution to the statistical analyses. This work was supported by the Intramural Research Program at the National Institute of Mental Health and the Department of Veterans Affairs. The contents of this manuscript do not represent the views of the Department of Veterans Affairs or the United States.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Stephen Correia
    • 1
  • Emily Hubbard
    • 2
  • Jason Hassenstab
    • 3
  • Agustin Yip
    • 4
  • Josef Vymazal
    • 5
  • Vit Herynek
    • 6
  • Jay Giedd
    • 7
  • Dennis L. Murphy
    • 8
  • Benjamin D. Greenberg
    • 4
  1. 1.Department of Psychiatry and Human Behavior, Alpert Medical SchoolBrown UniversityProvidenceUSA
  2. 2.School of MedicineOregon Health and Science University School of MedicinePortlandUSA
  3. 3.Department of Psychiatry and Human Behavior, Alpert Medical SchoolBrown UniversityProvidenceUSA
  4. 4.Butler Hospital, Department of Psychiatry and Human Behavior, Alpert Medical SchoolBrown UniversityProvidenceUSA
  5. 5.MR Unit, Department of RadiodiagnosticsHospital Na HomolcaPragueCzech Republic
  6. 6.MRI Unit, Department of Radiodiagnostic and Interventional RadiologyInstitute for Clinical and Experimental MedicinePragueCzech Republic
  7. 7.Unit on Brain Imaging, Clinical Psychiatry Branch NIMH Intramural Research CenterNIH Clinical CenterBethesdaUSA
  8. 8.Laboratory of Clinical ScienceNIMH Intramural Research ProgramBethesdaUSA

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