Brain Activity Dissociates Mentalization from Motivation During an Interpersonal Competitive Game
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Studies demonstrating selective brain networks subserving motivation and mentalization (i.e. attributing states of mind to others) during social interactions have not investigated their mutual independence. We report the results of two fMRI studies using a competitive game requiring players to use implicit ‘on-line’ mentalization simultaneously with motivational processes of gains and losses in playing against a human or a computer opponent. We delineate a network, consisting of bilateral temporoparietal junction, temporal pole (TP), medial prefrontal cortex (MPFC) and right fusiform gyrus, which is sensitive to the opponent’s response (challenging>not challenging the player) and opponent type (human>computer). This network is similar to a known explicit ‘off-line’ mentalization circuit, suggesting its additional involvement in implicit ‘on-line’ mentalization, a process more applicable to real-life social interactions. Importantly, only MPFC and TP were selective to mentalization compared to motivation, highlighting their specific operation in attributing states of mind to others during social interactions.
KeywordsTheory of mind Reward Medial prefrontal cortex Temporoparietal junction Temporal pole
The authors would like to thank Drs. Kristen McKiernan Miller, Michael Stevens and Brian Knutson for their helpful comments on earlier versions of the manuscript. This work was partially supported by a Hartford Hospital grant (PI: M. Assaf).
- Bush, G., Vogt, B. A., Holmes, J., Dale, A. M., Greve, D., Jenike, M. A., et al. (2002). Dorsal anterior cingulate cortex: a role in reward-based decision making. Proceedings of the National Academy of Sciences of the United States of America, 99, 523–528. doi: 10.1073/pnas.012470999.PubMedCrossRefGoogle Scholar
- Dale, A. M., & Buckner, R. L. (1997). Selective averaging of rapidly presented individual trials using fMRI. Human Brain Mapping, 5, 329–340. doi: 10.1002/(SICI)1097-0193(1997)5:5<329::AID-HBM1>3.0.CO;2-5.CrossRefGoogle Scholar
- First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (2002). Structured Clinical Interview for DSM-IV-TR axis I disorders, research version, patient edition. (SCID-I/P). New York: Biometrics Research, New York State Psychiatric Institute.Google Scholar
- Pochon, J. B., Levy, R., Fossati, P., Lehericy, S., Poline, J. B., Pillon, B., et al. (2002). The neural system that bridges reward and cognition in humans: an fMRI study. Proceedings of the National Academy of Sciences of the United States of America, 99, 5669–5674. doi: 10.1073/pnas.082111099.PubMedCrossRefGoogle Scholar
- Rutkowski, R. G., & Weinberger, N. M. (2005). Encoding of learned importance of sound by magnitude of representational area in primary auditory cortex. Proceedings of the National Academy of Sciences of the United States of America, 102, 13664–13669. doi: 10.1073/pnas.0506838102.PubMedCrossRefGoogle Scholar
- Schultz, R. T., Grelotti, D. J., Klin, A., Kleinman, J., Van der Gaag, C., Marois, R., et al. (2003). The role of the fusiform face area in social cognition: implications for the pathobiology of autism. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 358, 415–427. doi: 10.1098/rstb.2002.1208.PubMedCrossRefGoogle Scholar
- Talairach, J., & Tournoux, P. (1988). A co-planar stereotaxic atlas of a human brain. New York: Thieme.Google Scholar