Brain Imaging and Behavior

, Volume 2, Issue 3, pp 192–199

Neural Correlates of Visuospatial Working Memory in Healthy Young Adults at Risk for Hypertension

  • Andreana P. Haley
  • John Gunstad
  • Ronald A. Cohen
  • Beth A. Jerskey
  • Richard C. Mulligan
  • Lawrence H. Sweet
Article

DOI: 10.1007/s11682-008-9025-4

Cite this article as:
Haley, A.P., Gunstad, J., Cohen, R.A. et al. Brain Imaging and Behavior (2008) 2: 192. doi:10.1007/s11682-008-9025-4

Abstract

Family history of hypertension (FH+) has been associated with subtle deficits in cognitive function. In search of an early marker that may identify individuals predisposed to developing cognitive difficulties, we employed fMRI to test for FH+ related differences in hemodynamic response to a working memory challenge in healthy young adults with intact working memory. Fourteen healthy adults (ages 18 to 40 years) participated in an fMRI study of working memory. Seven of the participants were FH+. Groups were matched for working memory performance. Relative to FH− controls, FH+ participants exhibited lower 2-Back-related activation in the right inferior parietal lobule and the right inferior temporal gyrus as well as significantly more deactivation in the posterior cingulate cortex. These results indicate that FH+ is associated with subtle changes in visuospatial attention even in healthy young adults.

Keywords

Hypertension Attention fMRI Cognition Genetic risk Family history 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Andreana P. Haley
    • 1
  • John Gunstad
    • 2
  • Ronald A. Cohen
    • 3
  • Beth A. Jerskey
    • 3
  • Richard C. Mulligan
    • 3
  • Lawrence H. Sweet
    • 3
  1. 1.Department of PsychologyThe University of Texas at AustinAustinUSA
  2. 2.Department of PsychologyKent State UniversityKentUSA
  3. 3.Department of Psychiatry and Human BehaviorWarren Alpert Medical School of Brown UniversityProvidenceUSA

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