Brain Imaging and Behavior

, Volume 2, Issue 1, pp 21–26

Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals—A Preliminary Voxel Based Morphometry Study

  • Shashwath A. Meda
  • Joel Gelernter
  • Jeffrey R. Gruen
  • Vince D. Calhoun
  • Haiying Meng
  • Natalie A. Cope
  • Godfrey D. Pearlson



The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals.


Fifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups.


Individuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/parahippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner.


These data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals.


Structural imaging Polymorphism VBM Dyslexia Language 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Shashwath A. Meda
    • 1
  • Joel Gelernter
    • 2
    • 4
    • 8
  • Jeffrey R. Gruen
    • 3
    • 5
  • Vince D. Calhoun
    • 1
    • 2
    • 6
    • 7
  • Haiying Meng
    • 5
  • Natalie A. Cope
    • 5
  • Godfrey D. Pearlson
    • 1
    • 2
  1. 1.Olin Neuropsychiatry Research CenterInstitute of Living at Hartford HospitalHartfordUSA
  2. 2.Department of PsychiatryYale University School of MedicineNew HavenUSA
  3. 3.Department of GeneticsYale University School of MedicineNew HavenUSA
  4. 4.Department NeurobiologyYale University School of MedicineNew HavenUSA
  5. 5.Department of Pediatrics, Yale Child Health Research CenterYale University School of MedicineNew HavenUSA
  6. 6.The MIND InstituteAlbuquerqueUSA
  7. 7.Department of ECEUniversity of New MexicoAlbuquerqueUSA
  8. 8.VA CT Healthcare CenterWest HavenUSA

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