Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals—A Preliminary Voxel Based Morphometry Study
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The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals.
Fifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups.
Individuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/parahippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner.
These data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals.
KeywordsStructural imaging Polymorphism VBM Dyslexia Language
The authors would like to thank Ann Marie Lacobelle and Greg Kay for technical assistance. This research was supported in part by grants from the National Institutes of Health, under RO1 grants MH60504, MH43775, MH52886 and an NIMH MERIT award (to GP) 1 R01 EB 000840 and 1 R01 EB 005846, R01 DA12690, R01 DA12849, K24 DA15105; 1 R01 NS43530 to JRG; the U.S. Department of Veterans Affairs (the VA Connecticut–Massachusetts Mental Illness Research, Education and Clinical Center [MIRECC]) to JG; a Hartford Hospital Open Grant Award, and a National Association for Research in Schizophrenia and Affective Disorders Young Investigator Award to VC.
Support for HM is from a General Grant Award of the International Dyslexia Association.
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