Chinese Journal of Cancer Research

, Volume 24, Issue 4, pp 261–262 | Cite as

The hedgehog pathway in breast cancer

Editorial

References

  1. 1.
    Forouzanfar MH, Foreman KJ, Delossantos AM, et al. Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet 2011;378:1461–1484.PubMedCrossRefGoogle Scholar
  2. 2.
    Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004;432:324–331.PubMedCrossRefGoogle Scholar
  3. 3.
    Rubin LL, de Sauvage FJ. Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov 2006;5:1026–1033.PubMedCrossRefGoogle Scholar
  4. 4.
    Watkins DN, Berman DM, Burkholder SG, et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003;422:313–317.PubMedCrossRefGoogle Scholar
  5. 5.
    Karhadkar SS, Bova GS, Abdallah N, et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 2004;431:707–712.PubMedCrossRefGoogle Scholar
  6. 6.
    El-Zaatari M, Tobias A, Grabowska AM, et al. Deregulation of the sonic hedgehog pathway in the InsGas mouse model of gastric carcinogenesis. Br J Cancer 2007;96:1855–1861.PubMedCrossRefGoogle Scholar
  7. 7.
    Cui W, Wang LH, Wen YY, et al. Expression and regulation mechanisms of Sonic Hedgehog in breast cancer. Cancer Sci 2010;101:927–933.PubMedCrossRefGoogle Scholar
  8. 8.
    Souzaki M, Kubo M, Kai M, et al. Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer. Cancer Sci 2011;102:373–381.PubMedCrossRefGoogle Scholar
  9. 9.
    Feldmann G, Dhara S, Fendrich V, et al. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res 2007;67:2187–2196.PubMedCrossRefGoogle Scholar
  10. 10.
    Nagai S, Nakamura M, Yanai K, et al. Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation. Cancer Sci 2008;99:1377–1384.PubMedCrossRefGoogle Scholar
  11. 11.
    Ruel L, Rodriguez R, Gallet A, et al. Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. Nat Cell Biol 2003;5:907–913.PubMedCrossRefGoogle Scholar
  12. 12.
    Lewis MT. Hedgehog signaling in mouse mammary gland development and neoplasia. J Mammary Gland Biol Neoplasia 2001;6:53–66.PubMedCrossRefGoogle Scholar
  13. 13.
    Lewis MT, Ross S, Strickland PA, et al. Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1. Development 1999;126:5181–5193.PubMedGoogle Scholar
  14. 14.
    Bai CB, Stephen D, Joyner AL. All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev Cell 2004;6:103–115.PubMedCrossRefGoogle Scholar
  15. 15.
    Kasper M, Regl G, Frischauf AM, et al. GLI transcription factors: mediators of oncogenic Hedgehog signalling. Eur J Cancer 2006;42:437–445.PubMedCrossRefGoogle Scholar
  16. 16.
    Kubo M, Nakamura M, Tasaki A, et al. Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res 2004;64:6071–6074.PubMedCrossRefGoogle Scholar
  17. 17.
    Wang H, Mao XY, Zhao TT, et al. Study on the skip metastasis of axillary lymph nodes in breast cancer and their relation with Gli1 expression. Tumour Biol 2012. [Epub ahead of print].Google Scholar
  18. 18.
    Kameda C, Tanaka H, Yamasaki A, et al. The Hedgehog pathway is a possible therapeutic target for patients with estrogen receptor-negative breast cancer. Anticancer Res 2009;29:871–879.PubMedGoogle Scholar
  19. 19.
    Ramaswamy B, Lu Y, Teng KY, et al. Hedgehog Signaling Is a Novel Therapeutic Target in Tamoxifen-Resistant Breast Cancer Aberrantly Activated by PI3K/AKT Pathway. Cancer Res 2012;72:5048–5059.PubMedCrossRefGoogle Scholar
  20. 20.
    Sekulic A, Migden MR, Oro AE, Dirix L, et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med 2012;366:2171–2179.PubMedCrossRefGoogle Scholar

Copyright information

© Chinese Anti-Cancer Association and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Medical OncolgyTemple University HospitalPhiladelphiaUSA
  2. 2.Medical Oncologist/Hematologist, St Luke’s Health SystemTemple University Medical SchoolBethlehemUSA

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