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Chinese Journal of Cancer Research

, Volume 23, Issue 1, pp 33–37 | Cite as

Plasma vitamin D levels and vitamin D receptor polymorphisms are associated with survival of non-small cell lung cancer

  • Yao Liu
  • Wei Chen
  • Zhi-bin Hu
  • Lin Xu
  • Yong-qian Shu
  • Shi-yang Pan
  • Jun-cheng Dai
  • Guang-fu Jin
  • Hong-xia Ma
  • Hong-bing ShenEmail author
Original Article

Abstract

Objective

Vitamin D and its receptor (VDR) involve in multiple cellular processes and play an important role in the initiation and progression of malignancy. Thus we hypothesized that plasma vitamin D levels and single nucleotide polymorphisms (SNPs) in VDR may be of prognostic significance in non-small cell lung cancer (NSCLC).

Methods

We examined plasma 25-hydroxyvitamin D [25(OH)D] levels in 87 patients diagnosed with NSCLC using enzyme-linked immunosorbent assay (ELISA) and genotyped seven potentially functional SNPs in VDR in 568 NSCLC patients on Illumina Golden Gate platform.

Results

Patients with higher plasma 25(OH)D levels had worse survival than patients with lower ones (P for trend = 0.048). The SNPs of rs1544410 and rs739837 were independently associated with NSCLC survival (adjusted HR = 1.61, 95% CIs = 1.06-2.45 for rs739837 AA vs AC/CC and adjusted HR = 1.51, 95% CIs = 1.06-2.16 for rs1544410 AG/AA vs GG). A joint effect was observed between rs1544410 and rs739837 and the risk of death elevated as the number of unfavourable genotypes patients carried increased (P for trend = 0.003). There were no significant associations between VDR polymorphisms and plasma 25(OH)D levels.

Conclusion

Our findings indicate that plasma 25(OH)D levels and genetic variants of VDR may serve as prognostic markers for NSCLC in this Chinese population.

Key words

Vitamin D receptor polymorphisms Non-small cell lung cancer Chinese population Prognosis 

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Copyright information

© Chinese Anti-Cancer Association and Springer Berlin Heidelberg 2011

Authors and Affiliations

  • Yao Liu
    • 1
  • Wei Chen
    • 1
  • Zhi-bin Hu
    • 1
    • 5
  • Lin Xu
    • 2
  • Yong-qian Shu
    • 3
  • Shi-yang Pan
    • 4
  • Jun-cheng Dai
    • 1
  • Guang-fu Jin
    • 1
    • 5
  • Hong-xia Ma
    • 1
  • Hong-bing Shen
    • 1
    • 5
    Email author
  1. 1.Department of Epidemiology and Biostatistics, School of Public HealthNanjing Medical UniversityNanjingChina
  2. 2.Department of Thoracic SurgeryJiangsu Cancer HospitalNanjingChina
  3. 3.Department of Oncology, Jiangsu Key Discipline of Medicine, the First Affiliated HospitalNanjing Medical UniversityNanjingChina
  4. 4.Department of Laboratory Diagnosis, the First Affiliated HospitalNanjing Medical UniversityNanjingChina
  5. 5.Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and TreatmentCancer CenterNanjingChina

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