Antioxidant enzymes and cancer
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Although oxidation is the most common biological and energy producing reaction, oxidative stress is harmful to cell, because the products of oxidation such as free radicals and peroxides damage the cellular components, causing several diseases. Damage in DNA is responsible for cancer formation and progression. However, several enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase etc. act as antioxidants to influence oxidative stress. Polymorphisms in these enzymes are supposed to be associated with DNA damage and subsequently the individual’s risk of cancer susceptibility. This review article aims to further elucidate the relationship between antioxidant enzymes and cancers by summarizing the findings of some of the important study concerning expression levels and genetic polymorphisms of antioxidant enzymes in cancer patients.
KeywordsSuperoxide dismutase Catalase Glutathione peroxidase Glutathione-S-Transferase Cancer
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- Champe PC, Harvey RA, Ferrier DR. Intermediary metabolism. Champe PC, Lippincott’s Illustrated Reviews: Biochemistry. 4th edition[M]. Lippincott Williams & Wilkins. Philadelphia, USA. 2007; p: 69–82, 148.Google Scholar
- Bagchi K, Puri S. Free radicals and antioxidants in health and disease[J]. Eastern Mediterranean Health Journal 1998; 4: 350–360.Google Scholar
- Frederiks WM, Bosch KS, Hoeben KA, et al. Renal cell carcinoma and oxidative stress: The lack of peroxisomes[J]. Acta Histochem 2009; Jun 3 [Epub ahead of print]Google Scholar
- Surapaneni KM, Sadagopan C. Status of Lipid peroxidation and antioxidant enzymes in patients with carcinoma of breast[J]. J Med Sci Res 2007; 1: 21–24.Google Scholar
- Houlstone RS. Glutathione S-transferase M1 status and lung cancer risk: A meta-analysis[J]. Cancer Epidemiol Biomark Prev 1999; 8: 675–682.Google Scholar
- Gokul S, Patil V, Jailkhani R, et al. Oxidantantioxidant status in blood and tumor tissue of oral squamous cell carcinoma patients[J]. Oral Dis 2009; Jul 27 [Epub ahead of print].Google Scholar