Risk analysis of hepatocellular carcinoma in Northeast China

  • Zhi-fang Jia
  • Meng Su
  • Miao He
  • Zhi-hua Yin
  • Wei Wu
  • Xue-lian Li
  • Peng Guan
  • Bao-sen Zhou
Liver Cancer



It is known that chronic hepatitis B virus (HBV) infection is a main risk factor for hepatocellular carcinoma (HCC). To assess the effect of HBV infection and its interaction with other factors on the risk for HCC, a hospital-based case-control study was carried out in Northeast China.


A total of 384 cases with hepatocellular carcinoma and 432 controls without evidence of liver diseases were enrolled in the study. Blood samples were collected to detect the serum markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) and questionnaires about lifestyle and family tumor history were performed in all subjects.


The total infection rate of HBV in hepatocellular carcinoma cases was 70.8% and 10.0% in non-liver disease controls. There was a statistically significant difference (P<0.0001) between cases and controls (OR= 22.0; 95%CI:15.0–32.3). Interaction analysis indicated that in HBV chronic carriers with HCV infection or alcohol consumption or family HCC history, the risk for HCC increased (OR=41.1, 95%CI: 20.2–83.9, OR=125.0, 95%CI: 66.5–235.2; OR=56.9, 95%CI: 27.2–119.3 respectively). In addition, hepatitis B history, HCV infection, hepatic cirrhosis and family history of HCC were also potential HCC independent risk factors.


We confirmed that HBV is a chief risk factor for hepatocellular carcinoma and accounts for 67.7% of all hepatocellular carcinoma in Northeast China. HCV infection, alcohol intake and family history could enhance the risk for HCC in chronic HBV carriers.

Key Words

Hepatitis B virus Hepatocellular carcinoma Risk factors 

CLC number



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Copyright information

© Chinese Anti-Cancer Association and Springer Berlin Heidelberg 2009

Authors and Affiliations

  • Zhi-fang Jia
    • 1
  • Meng Su
    • 2
  • Miao He
    • 3
  • Zhi-hua Yin
    • 1
  • Wei Wu
    • 1
  • Xue-lian Li
    • 1
  • Peng Guan
    • 1
  • Bao-sen Zhou
    • 1
  1. 1.Department of Epidemiology and Key Laboratory of Cancer Etiology and Intervention of Liaoning Province, School of Public HealthChina Medical UniversityShenyangChina
  2. 2.Department of Medical OncologyCancer Hospital of Liaoning ProvinceShenyangChina
  3. 3.Information Center, the First Affiliated HospitalChina Medical UniversityShenyangChina

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