Chinese Journal of Cancer Research

, Volume 17, Issue 1, pp 11–16 | Cite as

Gene expression profiling of ganglioglioma malignant progression by cDNA array

  • Zhang Quan-bin 
  • Huang Qiang 
  • Dong Jun 
  • Wang Ai-dong 
  • Sun Ji-yong 
  • Lan Qing 
  • Hu Geng-xi 
Articles
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Accepted:
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Abstract

Objective: To establish gene expression profiles associated with malignant progression of ganglioglioma. Methods: The primary and two recurrent glioma specimens were collected intraoperatively from the same patient who experienced tumor transformation into anaplastic astrocytoma and glioblastoma multiform for the first and second recurrence respectively. Gene expression was assayed through cDNA array and bioinformatics analysis. Results: A total of 197 differentially expressed genes with differential ratio value more than 3 compared with normal brain tissue were obtained. Among 109 functionally denned genes, those associated with development ranked the first by frequency, followed by genes associated with metabolism, differentiation, signal transduction and so on. As a result of cluster analysis among 368 genes, eleven genes were up regulated with malignant progression, while six genes were down regulated. Conclusion: Gene expression profiles associated with malignant progression of glioma were successfully established, which provides a powerful tool for research on molecular mechanisms of malignant progression of gliomas.

Key words

cDNA microarray Glioma Gene expression profile Malignant progression 

CLC number

R739.41 
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Copyright information

© Chinese Journal 2005

Authors and Affiliations

  • Zhang Quan-bin 
    • 1
  • Huang Qiang 
    • 1
  • Dong Jun 
    • 1
  • Wang Ai-dong 
    • 1
  • Sun Ji-yong 
    • 1
  • Lan Qing 
    • 1
  • Hu Geng-xi 
    • 2
  1. 1.Department of Neurosurgery and Brain Tumor Research Laboratory, The 2nd Affiliated HospitalSoochow UniversitySuzhou
  2. 2.Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai

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