Abstract
Objective: To identify the relation between nasopharyngeal carcinoma and the human novel gene UBAP1, which is located in the region of minimal heterozygosity deletion at 9pl3.2 and down-expressed in NPC. Methods: Five single nucleotide polymorphisms (SNPs) within UBAP1 gene were analysed by sequencing in 105 NPC patients and 183 control subjects which matched to the NPC cases on age, sex and residence. Results: Significant association was found between NPC with one SNP mark (rslO49557), which is located at 3′ non-region of UBAP1 gene; the relative risk of this SNP mark is 1.64 (genotype GG) and 1.31 (genotype CG). Conclusion: The result has proved again that UBAP1 gene may play a certain role in the occurrence and development of nasopharyngeal carcinoma. The SNP mark rslO49557, considering its location, may influence the expression of UBAP1 gene.
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Foundation item: This work was supported by a grant from the National “863” High-Tech Program of China (No. 2001AA221031) and a grant from the National Natural Science Foundation of China (No.30100027).
Biography: ZENG Zhao-yang (1974-), female, bachelor of medicine, assistant professor, Xiangya School of Medicine, Central South University, majors in oncology.
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Zeng, Zy., Xiong, W., Xiong, F. et al. Case-control association studies of the UBAP1 gene and nasopharyngeal carcinoma in southern Chinese. Chin J Cancer Res 15, 157–160 (2003). https://doi.org/10.1007/s11670-003-0018-y
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DOI: https://doi.org/10.1007/s11670-003-0018-y