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Electrochemical Determination of Baicalin in Traditional Chinese Medicine Based on the Enhancement Effect of MoO3-Reduced Graphene Oxide Nanocomposite

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Abstract

The nanocomposites of MoO3-reduced graphene oxide (MoO3-RGO) were synthesized by hydrothermal reduction using MoCl5 and graphene oxide as precursors. The resulting composites were characterized with scanning electron microscopy, x-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis and Raman spectra, and were further used to modify the glassy carbon electrode (GCE). After optimizing the parameters, the electrochemical behavior of baicalin on different types of electrodes was investigated. The MoO3-RGO composite-modified GCE exhibited remarkably enhanced electrochemical signals of baicalin. After 90 s, under open circuit potential, oxidation and reduction peaks appeared at 0.207 V and 0.103 V, respectively. A sensitive and simple electrochemical method was proposed for the determination of baicalin in which the calibration curve ranges from 1.0 × 10−9 M to 4.3 × 10−5 M, and the detection limit is 3.81 × 10−10 M.

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Authors and Affiliations

  1. Hubei Key Laboratory of Biological Resources Protection and Utilization, Hubei University for Nationalities, Enshi, 445000, China

    Weibing Hu, Wen Zhang, Meng Wang & Fu Feng

  2. School of Chemical and Environmental Engineering, Hubei University for Nationalities, Enshi, 445000, China

    Weibing Hu, Wen Zhang, Meng Wang & Fu Feng

Authors
  1. Weibing Hu
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  2. Wen Zhang
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  3. Meng Wang
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  4. Fu Feng
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Correspondence to Weibing Hu.

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Hu, W., Zhang, W., Wang, M. et al. Electrochemical Determination of Baicalin in Traditional Chinese Medicine Based on the Enhancement Effect of MoO3-Reduced Graphene Oxide Nanocomposite. J. Electron. Mater. 47, 1151–1157 (2018). https://doi.org/10.1007/s11664-017-5899-5

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  • DOI: https://doi.org/10.1007/s11664-017-5899-5

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