Two-Step Hydrothermal Synthesis of Bifunctional Hematite–Silver Heterodimer Nanoparticles for Potential Antibacterial and Anticancer Applications
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In recent years, the development of composite nanostructures containing noble metal and magnetic nanocrystals has attracted much interest because they offer a promising avenue for multifunctional applications in nanomedicine and pharmacotherapy. In this work, we present a facile two-step hydrothermal approach for the synthesis of bifunctional heterodimer nanoparticles (HDNPs) composed of hematite nanocubes (α-Fe2O3 NCs) and silver nanoparticles (Ag-NPs). The formation and magnetic property of α-Fe2O3-Ag HDNPs was analyzed by transmission electron microscopy, x-ray diffraction and vibrating sample magnetometer. Interestingly, the hydrothermal-synthesized α-Fe2O3-Ag HDNPs were found to display significant antibacterial activity against three types of infectious bacteria. The cytotoxicity of α-Fe2O3-Ag nanocomposite against lung cancer A549 cell line was investigated and compared with that of pure α-Fe2O3 NCs and Ag-NPs. The obtained results reveal that the α-Fe2O3-Ag nanocomposite exhibited higher anticancer performance than that of pure Ag-NPs, whereas pure α-Fe2O3 NCs were not cytotoxic to the tested cells. The inhibitory concentration (IC50) of the α-Fe2O3-Ag nanocomposite was found at 20.94 μg/mL. With the aforementioned properties, α-Fe2O3-Ag HDNPs showed a high potential as a multifunctional material for advanced biomedicine and nanotherapy applications.
KeywordsFe2O3-Ag magnetic nanocomposites antibacterial anticancer hydrothermal synthesis
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This research was funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant Number 106-YS.99-2014.19. The authors would like to acknowledge the technical supports for antibacterial measurements at National Institute of Hygiene and Epidemiology (NIHE) and for cytotoxicity analyses at National Institute of Medicinal Materials (NIMM) in Hanoi, Vietnam.
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