Physiopathologie de l’hyperactivité vésicale

  • J. Kerdraon
  • A. Manunta
  • P. Coignard
  • L. Siproudhis
Article de Synthèse / Review Article
First Online:

Résumé

L’hyperactivité vésicale est définie comme un trouble de la continence associant une urgenturie avec ou sans incontinence, et fréquemment associée à une pollakiurie et à une nycturie. Un ensemble d’observations récentes permet en effet, désormais, d’établir que l’hyperactivité vésicale correspond d’abord à une anomalie du traitement sensoriel régulant la continence. Les différents cadres étiopathogéniques chez l’homme partagent un ensemble de désordres similaires au niveau de l’urothélium, des nerfs et du muscle lisse du détrusor. Ces désordres s’inscrivent pour partie dans le cadre d’une neuroplasticité orchestrée par les facteurs de croissance nerveuse.

Mots clés

Hyperactivité vésicale Urgenturie Pathophysiologie Neuroplasticité 

Pathophysiology of bladder overactivity

Abstract

Overactive bladder (OAB) is characterised by the storage symptoms of urgency, with or without incontinence, and usually with urinary frequency and nocturia. Recent findings establish that OAB may first refer to abnormal sensory processing of continence. The various pathologic conditions associated with OAB share common features of altered function of urothelium, innervation and detrusor smooth muscle, and may partly rely on growth factors that orchestrate neural plasticity.

Keywords

Overactive bladder Urgency Pathophysiology Neuroplasticity 
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Copyright information

© Springer-Verlag France 2010

Authors and Affiliations

  • J. Kerdraon
    • 1
    • 2
  • A. Manunta
    • 2
  • P. Coignard
    • 1
  • L. Siproudhis
    • 2
  1. 1.Service de rééducation neurologique adulteCMRRF KerpapePloemeur cedexFrance
  2. 2.Pavillon Pointeau du Ronceray, centre de référence spina bifidaCHU PontchaillouRennesFrance

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