Association between serum high-density lipoprotein cholesterol and bone health in the general population: a large and multicenter study
- 46 Downloads
This study was a cross-sectional study and enrolled 14,147 participants after excluding. We performed a large number of data analyses to indicate that HDL-C levels were related to bone health. A high HDL-C level is an independent risk factor for bone loss both in males and females.
Serum high-density lipoprotein cholesterol (HDL-C), usually called “good” cholesterol, is beneficial for preventing cardiovascular diseases. Previous studies have indicated that HDL-C levels may be related to bone mass. We performed a cross-sectional study to examine the relationship between HDL-C levels and bone mass, both in men and women.
A total of 14,147 Chinese participants from five medical centers were enrolled in this study. Pearson’s correlation analyses, linear regression analyses, one-way ANOVAs, and logistic regression analyses were performed to assess the relationship between HDL-C levels and bone mass in various cohorts.
Binary logistic regression analyses (after adjusting the confounding factors) indicated that a higher HDL-C level among males leads to a higher risk of at least osteopenia [OR (95% CI) = 1.807 (1.525, 2.142)] and osteoporosis [OR (95% CI) = 1.932 (1.291, 2.892)]. In the female group, the ORs of HDL-C for at least osteopenia [OR (95% CI) = 1.390 (1.100, 1.757)] and osteoporosis [OR (95% CI) = 1.768 (1.221, 2.560)] were still significant after adjusting for potential confounding factors except BMI. Data-standardized bivariate logistic regression analyses indicated that an increase in age is a stronger risk factor for osteoporosis and at least osteopenia than is higher HDL-C levels in females.
A high HDL-C level is an independent risk factor for bone loss both in males and females. Compared with high HDL-C levels, an increase in age and menopause have a much more negative effect on bone mass in females.
KeywordsHigh-density lipoprotein cholesterol Risk factor Bone mineral density Osteoporosis
body mass index
bone mineral density
blood urea nitrogen
low-density lipoprotein cholesterol
Chronic Kidney Disease Epidemiology Collaboration
glomerular filtration rate
systolic blood pressure
dual-energy x-ray absorptiometry
coefficient of variation
estimated renal function
This work was supported in part by the National Nature Science Fund of China (81702143, 81772387, and 81472064).
Compliance with ethical standards
Conflicts of interest
- 6.Bowe B, Xie Y, Xian H, et al. High Density Lipoprotein Cholesterol and the Risk of All-Cause Mortality among U.S. Veterans[J]. Clinical Journal of the American Society of Nephrology Cjasn, 2016, 11(10):1784Google Scholar
- 13.Choi HS, Kim KJKim K M, Hur N W, et al. (2010) Relationship between visceral adiposity and bone mineral density in Korean adults[J]. Calcif Tissue Int 87(3):218–225Google Scholar
- 32.Cauley JA (2015) Estrogen and bone health in men and women[J]. Steroids, 99(Pt A):11–15Google Scholar
- 34.Hsu YH, Venners SA, Terwedow HA, Feng Y, Niu T, Li Z, Laird N, Brain JD, Cummings SR, Bouxsein ML, Rosen CJ, Xu X (2006) Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women[J]. Am J Clin Nutr 83(1):146–154CrossRefGoogle Scholar