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Archives of Osteoporosis

, 13:123 | Cite as

Correspondence between bone mineral density and intervertebral disc degeneration across age and sex

  • Jarred KaiserEmail author
  • Brett Allaire
  • Paul M. Fein
  • Darlene Lu
  • Mohamed Jarraya
  • Ali Guermazi
  • Serkalem Demissie
  • Elizabeth J. Samelson
  • Mary L. Bouxsein
  • Elise F. Morgan
Original Article

Abstract

Summary

The distribution of bone tissue within the vertebra can modulate vertebral strength independently of average density and may change with age and disc degeneration. Our results show that the age-associated decrease in bone density is spatially non-uniform and associated with disc health, suggesting a mechanistic interplay between disc and vertebra.

Purpose

While the decline of bone mineral density (BMD) in the aging spine is well established, the extent to which age influences BMD distribution within the vertebra is less clear. Measures of regional BMD (rBMD) may improve predictions of vertebral strength and suggest how vertebrae might adapt with intervertebral disc degeneration. Thus, we aimed to assess how rBMD values were associated with age, sex, and disc height loss (DHL).

Methods

We measured rBMD in the L3 vertebra of 377 participants from the Framingham Heart Study (41–83 years, 181 M/196 F). Integral (Int.BMD) and trabecular BMD (Tb.BMD) were measured from QCT images. rBMD ratios (anterior/posterior, superior/mid-transverse, inferior/mid-transverse, and central/outer) were calculated from the centrum. A radiologist assigned a DHL severity score to adjacent intervertebral discs (L2–L3 and L3–L4).

Results

Int.BMD and Tb.BMD were both associated with age, though the decrease across age was greater in women (Int.BMD, − 2.6 mg/cm3 per year; Tb.BMD, − 2.6 mg/cm3 per year) than men (Int.BMD, − 0.5 mg/cm3 per year; Tb.BMD, − 1.2 mg/cm3 per year). The central/outer (− 0.027/decade) and superior/mid-transverse (− 0.018/decade) rBMD ratios were negatively associated with age, with similar trends in men and women. Higher Int.BMD or Tb.BMD was associated with increased odds of DHL after adjusting for age and sex. Low central/outer ratio and high anterior/poster and superior/mid-transverse ratios were also associated with increased odds of DHL.

Conclusions

Our results indicate that the distribution of bone within the L3 vertebra is different across age, but not between sexes, and is associated with disc degeneration.

Keywords

Aging Vertebral BMD Intervertebral disc degeneration 

Notes

Funding information

This study received funding from the National Institute of Health (R01AR054620, R01AR053986, and R01AG041658) and support from the Framingham Heart Study (NIH/NHLBI Contract HHSN268201500001I).

Compliance with ethical standards

Conflict of interest

Ali Guermazi is the President of Boston Imaging Core Lab, LLC. He is a Consultant to MerckSerono, GE, TissueGene, OrthoTrophix, AstraZeneca, Pfizer, and Sanofi.

Ethics statement

All participants signed written informed consent before enrollment and examination. Our study was approved by the Institutional Review Board at Boston University Medical Center.

Supplementary material

11657_2018_538_MOESM1_ESM.docx (22 kb)
ESM 1 (DOCX 21 kb)

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2018

Authors and Affiliations

  • Jarred Kaiser
    • 1
    Email author
  • Brett Allaire
    • 2
  • Paul M. Fein
    • 1
  • Darlene Lu
    • 3
  • Mohamed Jarraya
    • 4
    • 5
  • Ali Guermazi
    • 4
  • Serkalem Demissie
    • 3
  • Elizabeth J. Samelson
    • 6
    • 7
  • Mary L. Bouxsein
    • 2
    • 8
  • Elise F. Morgan
    • 1
  1. 1.Department of Mechanical EngineeringBoston UniversityBostonUSA
  2. 2.Center for Advanced Orthopedic StudiesBeth Israel Deaconess Medical CenterBostonUSA
  3. 3.Department of BiostatisticsBoston UniversityBostonUSA
  4. 4.Boston University School of MedicineBostonUSA
  5. 5.Department of RadiologyMercy Catholic Medical CenterDarbyUSA
  6. 6.Institute for Aging ResearchHebrew Senior LifeBostonUSA
  7. 7.Department of MedicineHarvard Medical SchoolBostonUSA
  8. 8.Dept of Orthopedic SurgeryHarvard Medical SchoolBostonUSA

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