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Archives of Osteoporosis

, 13:120 | Cite as

Individualized evaluation of lumbar bone mineral density in children with cerebral palsy

  • Ibrahim Duran
  • J. Katzmann
  • K. Martakis
  • C. Stark
  • O. Semler
  • E. Schoenau
Original Article

Abstract

Summary

Lumbar spine bone mineral density (LS-BMD) assessed by dual-energy X-ray absorptiometry (DXA) is used in children with cerebral palsy (CP) to evaluate bone health. LS-BMD results in children with CP are influenced significantly by their height, BMI, and mobility level. An adjustment for these parameters might improve the clinical significance of the method.

Purpose/introduction

DXA evaluation is considered useful in children with CP to assess bone health. For this purpose, LS-BMD is often used. The aim of the study was to estimate the effect of height, BMI, and reduced mobility level of children with CP on LS-BMD and to develop a method to adjust individual results of LS-BMD for these factors.

Methods

We conducted a monocentric retrospective analysis of data collected in children and adolescents with CP, who participated in a rehabilitation program and had no history of recurrent fractures. The DXA scan was part of the routine examination for participants older than 4 years of age. The relationship between height and BMI for age Z-scores and age-adjusted LS-BMD Z-scores was analyzed.

Results

LS-DXA scans of 500 children and adolescents with CP (Gross Motor Function Classification System levels I–V) were included in the statistical analysis (217 female). The mean age was 9.4 years (± 3.7 years). Children with moderate to severe CP had significantly (p < 0.001) lower LS-BMD Z-scores than children with mild CP. We provided nomograms to adjust individual LS-BMD results to their height, BMI, and mobility level.

Conclusions

LS-BMD results in children with CP were influenced significantly by their height, BMI, and mobility level. An adjustment of the LS-BMD results to height, BMI, and mobility level might improve the clinical significance of an individual result.

Keywords

Lumbar spine bone mineral density Functional muscle-bone unit Children Cerebral palsy 

Abbreviations

BAZ

BMI for age Z-score

BMD

Bone mineral density

BMAD

Bone mineral apparent density

DXA

Dual-energy X-ray absorptiometry

HAZ

Height for age Z-score

LS

Lumbar spine

SD

Standard deviation

TBLH

Total body less head

Notes

Compliance with ethical standards

After obtaining written informed consent of patients’ legal representatives for data analysis, data of the participants are stored in a prospective monocentric patient registry. The Ethics Committee of the University of Cologne approved this registry (16-269).

Conflicts of interest

None.

Supplementary material

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eFig 2

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2018

Authors and Affiliations

  • Ibrahim Duran
    • 1
  • J. Katzmann
    • 1
  • K. Martakis
    • 2
    • 3
  • C. Stark
    • 2
    • 4
  • O. Semler
    • 2
    • 5
  • E. Schoenau
    • 1
    • 2
  1. 1.Center of Prevention and Rehabilitation, UniRehaUniversity of CologneCologneGermany
  2. 2.Children’s and Adolescents’ HospitalUniversity of CologneCologneGermany
  3. 3.Department of International Health, School CAPHRI, Care and Public Health Research InstituteMaastricht UniversityMaastrichtthe Netherlands
  4. 4.Cologne Centre for Musculoskeletal BiomechanicsUniversity of CologneCologneGermany
  5. 5.Center for Rare Skeletal Diseases in ChildhoodUniversity of CologneCologneGermany

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