The effect of cholecystectomy on 25-hydroxyvitamin D levels and bone mineral density in postmenopausal women
Vitamin D deficiency has been reported in patients with gastrointestinal disorders. Little is known on the potentially deleterious effect of cholecystectomy on vitamin D levels and osteoporosis. We found that 25-hydroxyvitamin D levels and bone mineral density were lower in patients with prior cholecystectomy.
The influence of bile salts on vitamin D absorption is well-known, and increased incidence of vitamin D deficiency has been reported in patients with gastrointestinal disorders. Little is known on the potentially deleterious effect of cholecystectomy on vitamin D levels and osteoporosis. Herein, we aimed to investigate the effects of cholecystectomy on vitamin D levels and osteoporosis in postmenopausal women.
The study group comprised 50 postmenopausal women who had previously undergone cholecystectomy; the control group comprised 50 age-matched postmenopausal women. Serum vitamin D, calcium, and phosphorus levels were determined. Bone mineral density (BMD) was determined using dual-energy X-ray absorptiometry.
The study group had significantly higher parathyroid hormone levels (94.4 ± 45.1 vs. 69.2 ± 37.5, p < 0.001) but significantly lower 25-hydroxyvitamin D levels (16.3 ± 7.6 vs. 19.8 ± 8.7, p = 0.03). Compared with the control group, the BMDs of both the lumbar spine (− 1.5 ± 1.0 vs. − 0.9 ± 1.0, p = 0.004) and femur (− 0.5 ± 0.8 vs. 0.19 ± 1.1, p = 0.001) were significantly lower in the study group. Body mass index [B = 0.81 (CI 0.67–0.98), p = 0.03] and prior cholecystectomy [B = 7.9 (CI 1.0–71.7), p = 0.04] were independent predictors of osteoporosis.
In postmenopausal women, prior cholecystectomy is associated with lower serum 25-hydroxyvitamin D levels and BMD.
KeywordsOsteoporosis Cholecystectomy Vitamin D Postmenopausal women
Compliance with ethical standards
This cross-sectional analytical study was approved by the Research Ethics Committee of the Recep Tayyip Erdogan University Hospital. All participants provided written informed consent before participating in the study.
Conflicts of interest
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