Treatment patterns in patients with osteoporosis at high risk of fracture in Japan: retrospective chart review
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Osteoporosis (OP) causes reduced bone strength and increases risk of fractures. Medical records from specialist clinics in Japan of postmenopausal women with OP and high risk of fracture were analysed. Majority of patients were treated for OP as recommended and were prescribed OP medications soon after high-risk OP diagnosis.
The incidence of osteoporosis (OP) in Japan is predicted to increase significantly in coming decades. Resultant osteoporotic fractures are a significant contributor of economic and social burden among elderly osteoporosis patients. This retrospective chart review was conducted as a response to the current evidence gap in the treatment patterns for OP patients with high risk of fracture in Japan.
This was a multi-centre retrospective chart review that analysed data extracted from the medical records of postmenopausal OP patients at high risk for fracture who received care at 11 specialist clinics and medical centers in Japan for at least 18 to 24 months. Main outcome was OP treatment patterns.
The study included 709 eligible patients of whom 623 (87.9%) were prescribed OP medication during the study period. The most common reason for not taking OP medication was patient unwillingness to take medication. The most common OP medications prescribed initially were minodronic acid (20.1%), alendronate (19.9%), raloxifene (14.1%), weekly teriparatide acetate (12.4%) and eldecalcitol (11.4%). Majority of patients (62.1%) were still taking their initial medication at the end of the 18–24 month follow-up.
A high percentage of patients (87.9%) in Japan received OP medications soon after their high-risk diagnosis, with bisphosphonates, selective estrogen receptor modulators and teriparatide being the predominant treatment options.
KeywordsOsteoporosis Treatment patterns High risk of fracture Japan Retrospective chart review
The authors would like to thank the 11 site investigators (Osteoporosis Specialist) for conducting this study: Dr. Junichi Takada (Kitago Orthopedic Clinic, Hokkaido), Dr. Masanari Omata (Ooimachi Orthopaedic Surgery Clinic, Tokyo), Dr. Fumitoshi Ohmura (Koenji Orthopedic Clinic, Tokyo), Dr. Hiroaki Shibata (Shibata Orthopaedic Clinic, Tokyo), Dr. Masayuki Fukuchi (Fukuchi Clinic, Kikugawa-shi, Shizuoka), Dr. Akimitsu Miyauchi (Miyauchi Medical Center, Osaka), Dr. Hideki Tanaka (Okubo Hospital, Akashi-shi, Hyogo), Dr. Yasufumi Ohnishi (Onishi Medical Clinic, Kako-gun, Hyogo), Dr. Nobukazu Okimoto (Okimoto Clinic, Kures-hi, Hiroshima), Dr. Shigeki Hidaka (Hidaka Orthopedic Clinic, Kurume-shi, Fukuoka) and Dr. Shinobu Arita (Obase Hospital, Fukuoka).
Funding for this study was provided by Amgen Inc.
Compliance with ethical standards
Conflict of interest
Drs. Miyauchi and Fujiwara received consulting fees from Amgen Astellas BioPharma K.K. and Dr. Fujiwara is on the Speakers Bureau of Asahi-Kasei Pharma, Alere Medical and Pfizer. Ms. Nicholls is a full-time employee of MAPI Real World Evidence. Mr. Hamaya is a full-time employee of Amgen Astellas Biopharma K.K. and owns stock in Amgen, Inc. and Eli Lilly. Drs. Weston and Baidya are full-time employees of Optum. Mr. Barron and Mr. Pinto are full-time employees of and shareholders in Amgen Inc. Dr. Takada has no disclosures related to this manuscript.
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