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The vitamin D receptor expression in skeletal muscle of women with distal radius fracture

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Abstract

Summary

We evaluated the vitamin D receptor (VDR) expression in the forearm flexor muscle of women with distal radius fracture. High VDR expression was associated with low appendicular lean mass index.

Introduction

We aimed to evaluate the relationship between the VDR expression in the muscle cell and the muscle mass in women with a distal radius fracture (DRF).

Methods

We prospectively recruited 45 women over 50 years of age (mean age, 66 years) with DRF and acquired biopsy of the forearm flexor muscle. The muscle cross-sectional area (CSA) and VDR expression were measured using immunohistochemistry staining. The clinical parameters including grip strength, gait speed, body mass index (BMI), bone mineral density (BMD), and serum vitamin D levels were compared between patients grouped by appendicular lean mass index and were correlated with the VDR expression.

Results

Twelve patients (27%) showed a decreased appendicular lean mass index, less than the cut-off value of 5.4 kg/m2 which was suggested by the Asian Working Group for Sarcopenia. Patients with a low appendicular lean mass index had significantly lower muscle CSA (p = 0.037), but a higher VDR expression (p = 0.045) than those with higher indices. VDR expression was negatively correlated with BMI (r = − 0.417, p = 0.004) and appendicular lean mass index (r = − 0.316, p = 0.044).

Conclusions

DRF patients with low appendicular lean mass index presented high VDR expression and low CSA in forearm muscle cells. This suggests that the VDR expression might be upregulated in the attempt to compensate for the decreasing muscle mass. Further studies are necessary to explore the role of VDR in the progression of sarcopenia.

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Acknowledgments

This study was supported by a research fund (2015R1D1A1A01058562) from the National Research Foundation of Korea and in part by a basic research fund (14-2015-001) from the authors’ institution.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Hallym University College of Medicine, Chuncheon, South Korea

    Kahyun Kim

  2. Department of Orthopaedic Surgery, Seoul National University College of Medicine, Seoul, South Korea

    Hyun Sik Gong & Goo Hyun Baek

  3. Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, 300 Gumidong, Bundanggu, Seongnam, Gyeonggido, 463-707, Republic of Korea

    Hyun Sik Gong

  4. Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul, South Korea

    Jae-Young Lim

  5. Department of Physical Education, Hanyang University, Seoul, South Korea

    Jong Hee Kim

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  1. Kahyun Kim
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Correspondence to Hyun Sik Gong.

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The Seoul National University Bundang Hospital Institutional Review Board (SNUBH IRB) reviewed the protocol and approved the study (B-1501-282-002). All participants provided informed written consents.

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Kim, K., Gong, H.S., Lim, JY. et al. The vitamin D receptor expression in skeletal muscle of women with distal radius fracture. Arch Osteoporos 13, 24 (2018). https://doi.org/10.1007/s11657-018-0442-8

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