Chinese Journal of Integrative Medicine

, Volume 25, Issue 12, pp 895–901 | Cite as

Anti-obesity Effects of Ginsenosides in High-Fat Diet-Fed Rats

  • Hyun-Jung Park
  • Ji Hyun Kim
  • Insop ShimEmail author
Original Article



To examine the anti-obesity effects of ginsenosides in Korea Red Ginseng (KRG, Panax ginseng) in rats fed with a high-fat diet (HFD).


Twenty-five 4-week-old obesity rats after receiving an HFD for 5 weeks; subsequently, they were additionally treated with ginsenosides Rb1, Rd, Rg1, or Re (10 mg/kg, intraperitoneal injection) for a further 3 weeks (n=5 in each group). The control rats were fed a normal diet. The food consumption, body weight, locomotor activity, serum lipids, adipose tissues, nitric oxide (NO) expression, leptin, neuropeptide Y (NPY), cholecystokinin (CCK) in the brains were measured.


In the HFD-fed rats, body weight, body fat mass, serum levels of leptin and NO were significantly higher than in the control rats (P<0.05 or P<0.01). However, the treatment of Rd, Re, and Rb1 markedly decreased body fat mass and body weight (P<0.05). The serum level of leptin and NO in ginsenoside-treated rats were markedly lower than the control group (P<0.01). The expression of NPY and CCK in the hypothalamic nuclei showed insignificant difference among groups. However, the expression of NPY immunoreactive neurons in the hypothalamus was significantly reduced in the Rb1-treated group (P<0.05).


PD-type ginsenoside Rb1 from the crude saponins of KRG may be a useful compound for the treatment of obesity and related disorders through the modulation of peripheral and central appetite-regulating signals.


Panax ginseng ginsenosides hypothalamus obesity 


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Author Contributions

Shim IS, KIM JH and Park HJ designed the study. Park HJ and Kim JH acquired and analyzed the data. Park HJ, Kim JH and Shim IS wrote the article, which all other authors reviewed.

Supplementary material

11655_2019_3200_MOESM1_ESM.pdf (244 kb)
Anti-obesity Effects of Ginsenosides in High-Fat Diet-Fed Rats


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Copyright information

© The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Physiology, College of MedicineKyung Hee UniversitySeoulRepublic of Korea
  2. 2.Department of Food Science & BiotechnologyCollege of Science and EngineeringSuwon-siRepublic of Korea

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