Tiaobu Xinshen Recipe (调补心肾方) Improved Mild Cognitive Impairment of Alzheimer’s Disease Patients with Xin (Heart) and Shen (Kidney) Deficiency
To observe the intervention effects of Tiaobu Xinshen Recipe (调补心肾方, TXR) on patients with mild cognitive impairment caused by Alzheimer’s disease (MCI-AD).
Totally 88 MCI-AD patients with syndrome of Xin (Heart) and Shen (Kidney) deficiency were assigned to the experimental group (47 cases, treated with TXR) and the control group (41 cases, treated with donepezil hydrochloride) using a random number table. Final recruited qualified patients were 44 cases in the experimental group and 39 cases in the control group. The therapeutic course was 12 weeks. Neuropsychological scales [mini mental state examination (MMSE) and Montreal cognitive assessment (MoCA)], and Chinese medicine (CM) dementia syndromes scales were performed in all patients, and results were compared between groups or intra-group before and after treatment.
MMSE and MoCA scores of the two groups were increased after treatment compared with those before treatment (P<0.05). But there was no statistical difference in MMSE or MOCA scores after treatment between the two groups (P>0.05). CM dementia syndrome score was significantly decreased after treatment in the experimental group compared with the control group (P<0.01). Visual spatial and executive function scores and delayed recall scores of the two groups were increased compared with those before treatment (P<0.01).
TXR could effectively improve cognitive impairment of MCI-AD patients with syndrome of Xin and Shen deficiency.
KeywordsTiaobu Xinshen Recipe mild cognitive impairment Alzheimer’s disease mini mental state examination Montreal cognitive assessment Chinese medicine
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We are grateful to all the participants and staffs in the trial.
Lin ZY designed the research and analyzed the data. Lin ZY and Huang TW drafted the manuscript. Huang JS managed and coordinated the study. Zheng GY assisted with subject recruitment and supervised training sessions. All authors have read and approved the final version of the manuscript.
Conflict of Interest
All the authors declare that they have no competing interests.
- 1.Petersen RC. Mild cognitive impairment. Continuum (Minneap Minn) 2016;22 (2 Dementia):404–418.Google Scholar
- 3.Lin ZY, Huang TW, Huang JS, Zheng GY, Fu KL, Chen XY, et al. Nourishing Xin and Shen method improved mild cognitive impairment due to subcortical small vessel disease: a clinical study. Chin J Integr Tradit West Med (Chin) 2015;35:41–45.Google Scholar
- 4.Do LLTN. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders (DSM-JV). Encyclopedia of child behavior and development. Springer US, 2011:84-85.Google Scholar
- 5.Zheng XY, ed. Guidelines for clinical research of new drugs of traditional Chinese medicine. Beijing: China Medical Science and Technology Press; 2002:91–99.Google Scholar
- 8.Zheng GC, ed. Brain aging and senile dementia. Shanghai: Shanghai Science and Technology Press; 1995:229–231.Google Scholar
- 12.Zhou AH, Jia JP, Min BQ, Yang PJ. Comparison of neuropsychological features of mild cognitive impairment in different etiology. Chin J Neurol (Chin) 2008;41:242–246.Google Scholar
- 15.Lin SM, Wang J, Zhou RQ, Yu ZH. Clinical study of Alzheimer’s disease from Xin and Shen. Chin J Integr Tradit West Med (Chin) 2003;23:583–586.Google Scholar
- 17.Chen JX, Li ZW. Lu Xi’s experience in the treatment of senile dementia. Guangming J Chin Med (Chin) 2010;25:1140.Google Scholar