Chinese Journal of Integrative Medicine

, Volume 25, Issue 12, pp 883–886 | Cite as

Current Status and Problem-Solving Strategies for Ginseng Industry

  • Xiang-yan Li
  • Li-wei Sun
  • Da-qing ZhaoEmail author
Feature Article


Ginseng is a plant in the family Araliaceae and the genus Panax with the formal name of Panax ginseng C. A. Meyer and the treasure of traditional herbal medicine resources as the “king of herbs”. Ginseng has been traditionally used for over 2,000 years in Asian countries, especially in China and Republic of Korea. During the ginseng industry chain, the cultivation in farmland and seed breeding are important for sustainable development of ginseng resources. Active components in ginseng including ginsenosides, polysaccharides, phenolic compound and their therapeutic benefits for multiple diseases are being studied. This paper aimed to review current research status and problem-solving strategies for each step of ginseng industry, including ginseng growing cultivation and seed resources, basic and clinical studies as well as comparison of ginseng industry between China and Republic of Korea, hoping to provide a reference for research direction and future development of ginseng industry.


ginseng cultivation in farmland functional mechanism review 


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  1. 1.
    Park HJ, Kim DH, Park SJ, Kim JM, Ryu JH. Ginseng in traditional herbal prescriptions. J Ginseng Res 2012;36:225–241.CrossRefGoogle Scholar
  2. 2.
    Yun TK. Brief introduction of Panax ginseng C.A. Meyer. J Korean Med Sci 2001;16 (Suppl):S3–S5.CrossRefGoogle Scholar
  3. 3.
    Ogawa-Ochiai K, Kawasaki K. Panax ginseng for frailty-related disorders: A review. Front Nutr 2018;5:140.CrossRefGoogle Scholar
  4. 4.
    Kim KH, Lee D, Lee HL, Kim CE, Jung K, Kang KS. Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions. J Ginseng Res 2018;42:239–247.CrossRefGoogle Scholar
  5. 5.
    Baeg IH, So SH. The world ginseng market and the ginseng (Korea). J Ginseng Res 2013;37:1–7.CrossRefGoogle Scholar
  6. 6.
    Shin BK, Kwon SW, Park JH. Chemical diversity of ginseng saponins from Panax ginseng. J Ginseng Res 2015;39:287–298.CrossRefGoogle Scholar
  7. 7.
    Xin MT, Yang G, Tang XJ. Research on ginseng trade competitiveness between China and Korea. China J Chin Mater Med (Chin) 2017;42:1803–1807.Google Scholar
  8. 8.
    Shen L, Li XW, Xu J, Dong LL, Zhang NW, Naoli F, et al. Research on technology regulation of non-polluted cultivation and strategies of Panax ginseng cultivation in farmland. China J Chin Mater Med (Chin) 2017;42:3267–3274.Google Scholar
  9. 9.
    Shen L, Wu J, Li XW, Xu J, Dong LL, Sang MC, et al. A study of global ecological adaptability and field selection practices of Panax ginseng. China J Chin Mater Med (Chin) 2016;41:3314–3322.Google Scholar
  10. 10.
    Xu J, Dong LL, Wang R, Niu WH, Zhang NW, Naoki F, et al. Soil improvement promoted micro-ecology of farmlands for ginseng cultivation. China J Chin Mater Med (Chin) 2017;42:875–881.Google Scholar
  11. 11.
    Guo LL, Guo S, Dong LL, Shen L, Li XW, Xu J. et al. Key techniques for precision cultivation of nitrogenous fertilizer of pollution-free ginseng. China J Chin Mater Med (Chin) 2018;43:1427–1433.Google Scholar
  12. 12.
    Xiao C, Yang L, Zhang L, Liu C, Han M. Effects of cultivation ages and modes on microbial diversity in the rhizosphere soil of Panax ginseng. J Ginseng Res 2016;40:28–37.CrossRefGoogle Scholar
  13. 13.
    Shen L, Xu J, Dong LL, Li XW, Chen SL. Cropping system and research strategies in Panax ginseng. China J Chin Mater Med (Chin) 2015;40:3367–3373.Google Scholar
  14. 14.
    Lee JH, Lee JS, Kwon WS, Kang JY, Lee DY, In JG, et al. Characteristics of Korean ginseng varieties of gumpoong, sunun, sunpoong, sunone, cheongsun, and sunhyang. J Ginseng Res 2015;39:94–104.CrossRefGoogle Scholar
  15. 15.
    Wang K, Jiang S, Sun C, Lin Y, Yin R, Wang Y, et al. The spatial and temporal transcriptomic landscapes of Ginseng, Panax ginseng C. A. Meyer. Sci Rep 2015;5:18283.CrossRefGoogle Scholar
  16. 16.
    Yin R, Zhao M, Wang K, Lin Y, Wang Y, Sun C, et al. Functional differentiation and spatial-temporal co-expression networks of the NBS-encoding gene family in Jilin ginseng, Panax ginseng C.A. Meyer. PLoS One 2017;12:e0181596.CrossRefGoogle Scholar
  17. 17.
    Xu J, Chu Y, Liao B, Xiao S, Yin Q, Bai R, et al. Panax ginseng genome examination for ginsenoside biosynthesis. Gigascience 2017;6:1–15.PubMedPubMedCentralGoogle Scholar
  18. 18.
    Jayakodi M, Choi BS, Lee SC, Kim NH, Park JY, Jang W, et al. Ginseng genome database: an open-access platform for genomics of Panax ginseng. BMC Plant Biol 2018;18:62.CrossRefGoogle Scholar
  19. 19.
    So SH, Lee JW, Kim YS, Hyun SH, Han CK. Red ginseng monograph. J Ginseng Res 2018;42:549–561.CrossRefGoogle Scholar
  20. 20.
    Lee JW, Choi BR, Kim YC, Choi DJ, Lee YS, Kim GS, et al. Comprehensive profiling and quantification of ginsenosides in the root, stem, leaf, and berry of Panax ginseng by UPLC-QTOF/MS. Molecules 2017;22 2147.CrossRefGoogle Scholar
  21. 21.
    Yu S, Zhou X, Li F, Xu C, Zheng F, Li J, et al. Microbial transformation of ginsenoside Rb1, Re and Rg1 and its contribution to the improved anti-inflammatory activity of ginseng. Sci Rep 2017;7:138.CrossRefGoogle Scholar
  22. 22.
    Li B, Zhang N, Feng Q, Li H, Wang D, Ma L, et al. The core structure characterization and of ginseng neutral polysaccharide with the immune-enhancing activity. Int J Biol Macromol 2019;123:713–722.CrossRefGoogle Scholar
  23. 23.
    Li H, Song J, Zhang J, Wang T, Yan Y, Tao Z, et al. Ginseng protein reverses amyloid beta peptide and H2O2 cytotoxicity in neurons, and ameliorates cognitive impairment in AD rats induced by a combination of D-Galactose and AlCl3. Phytother Res 2017;31:284–295.CrossRefGoogle Scholar
  24. 24.
    Jang M, Choi JH, Chang Y, Lee SJ, Nah SY, Cho IH. Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington’s disease: activation of the Nrf2 pathway through lysophosphatidic acid receptors. Brain Behav Immun 2019;80:146–162.CrossRefGoogle Scholar
  25. 25.
    Chung IM, Lim JJ, Ahn MS, Jeong HN, An TJ, Kim SH. Comparative phenolic compound profiles and antioxidative activity of the fruit, leaves, and roots of Korean ginseng (Panax ginseng Meyer) according to cultivation years. J Ginseng Res 2016;40:68–75.CrossRefGoogle Scholar
  26. 26.
    Kim JH. Pharmacological and medical applications of Panax ginseng and ginsenosides: a review for use in cardiovascular diseases. J Ginseng Res 2018;42:264–269.CrossRefGoogle Scholar
  27. 27.
    Zheng M, Xin Y, Li Y, Xu F, Xi X, Guo H, et al. Ginsenosides: a potential neuroprotective agent. Biomed Res Int 2018;2018:8174345.PubMedPubMedCentralGoogle Scholar
  28. 28.
    Wong AS, Che CM, Leung KW. Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview. Nat Prod Rep 2015;32:256–272.CrossRefGoogle Scholar
  29. 29.
    Bai L, Gao J, Wei F, Zhao J, Wang D, Wei J. Therapeutic potential of ginsenosides as an adjuvant treatment for diabetes. Front Pharmacol 2018;9:423.CrossRefGoogle Scholar
  30. 30.
    Yang Y, Ren C, Zhang Y, Wu X. Ginseng: an nonnegligible natural remedy for healthy aging. Aging Dis 2017;8:708–720.CrossRefGoogle Scholar
  31. 31.
    Zhou SS, Xu J, Zhu H, Wu J, Xu JD, Yan R, et al. Gut microbiota-involved mechanisms in enhancing systemic exposure of ginsenosides by coexisting polysaccharides in ginseng decoction. Sci Rep 2016;6:22474.CrossRefGoogle Scholar
  32. 32.
    Shen H, Gao XJ, Li T, Jing WH, Han BL, Jia YM, et al. Ginseng polysaccharides enhanced ginsenoside Rb1 and microbial metabolites exposure through enhancing intestinal absorption and affecting gut microbial metabolism. J Ethnopharmacol 2018;216:47–56.CrossRefGoogle Scholar
  33. 33.
    He Y, Yang J, Lv Y, Chen J, Yin F, Huang J, et al. A review of ginseng clinical trials registered in the WHO International Clinical Trials Registry Platform. Biomed Res Int 2018;2018:1843142.PubMedPubMedCentralGoogle Scholar
  34. 34.
    Kim YS, Woo JY, Han CK, Chang IM. Safety analysis of Panax Ginseng in randomized clinical trials: a systematic review. Medicines (Basel) 2015;2:106–126.CrossRefGoogle Scholar
  35. 35.
    Komishon AM, Shishtar E, Ha V, Sievenpiper JL, de Souza RJ, Jovanovski E, et al. The effect of ginseng (genus Panax) on blood pressure: a systematic review and meta-analysis of randomized controlled clinical trials. J Hum Hypertens 2016;30:619–626.CrossRefGoogle Scholar
  36. 36.
    Yennurajalingam S, Tannir NM, Williams JL, Lu Z, Hess KR, Frisbee-Hume S, et al. A double-blind, randomized, placebo-controlled trial of Panax Ginseng for cancer-related fatigue in patients with advanced cancer. J Natl Compr Canc Netw 2017;15:1111–1120.CrossRefGoogle Scholar

Copyright information

© The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education; Jilin Provincial Key Laboratory of Bio-macromolecules of Chinese Medicine; Jilin Ginseng AcademyChangchun University of Chinese MedicineChangchunChina
  2. 2.Research Center of Traditional Chinese Medicinethe Affiliated Hospital to Changchun University of Chinese MedicineChangchunChina

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