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Research Progress on Chinese Medicine Immunomodulatory Intervention for Chronic Primary Immune Thrombocytopenia: Targeting Cellular Immunity

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Abstract

Chronic primary immune thrombocytopenia (CITP) is the most common acquired autoimmune disease that seriously threaten the physical and mental health of patients. Compared with Western medicine treatment, the intervention and treatment of Chinese medicine (CM) has shown certain therapeutic advantages. This paper reviewed the new pathogenesis progress on T cell immune abnormality in CITP, and CM studies on interferes effects of cellular immune regulation of CITP in recent years. Qi deficiency failing to control blood and internal obstruction of blood stasis are the two common types of CM syndromes in CITP patients, the corresponding treatments include invigorating Pi (Spleen), supplementing qi, activating blood, as well as tonifying qi and activating yang, regulating Gan (Liver) to invigorate Pi. The authors also mentioned the problems in the research field of CM for CTIP treatment, and put forward new ideas for the research in the future.

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Authors and Affiliations

  1. Institute of Hematology Research, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, China

    Wen-bin Liu, Sai Li, Xiao-ling Yu, Tie-ying Dai & Rui-lan Gao

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  1. Wen-bin Liu
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  2. Sai Li
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  3. Xiao-ling Yu
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  4. Tie-ying Dai
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  5. Rui-lan Gao
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Correspondence to Rui-lan Gao.

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Supported by the National Natural Science Foundation of China (No. 81774068), National Major Project for the Innovative New Drugs of “the 13th Five-year Plan” (No. 2016ZX09101071)

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Liu, Wb., Li, S., Yu, Xl. et al. Research Progress on Chinese Medicine Immunomodulatory Intervention for Chronic Primary Immune Thrombocytopenia: Targeting Cellular Immunity. Chin. J. Integr. Med. 25, 483–489 (2019). https://doi.org/10.1007/s11655-019-3031-9

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