Tetramethylpyrazine Improves Postoperative Tissue Adhesion: A Drug Repurposing

  • Shuai Yan
  • Yin-Zi Yue
  • Yang Zong
  • Li ZengEmail author


Plants are known to possess plenty of pharmacological activities as a result of various phytoconstituents. Tetramethylpyrazine (TMP), one of the most widely used medicinal compound isolated from traditional Chinese herb, is usually employed for anti-oxidation, anti-inflammation, anti-platelet aggregation, anti-lipid, anti-fibrosis, as well as activating blood, removing stasis, dilating small arteries, improving microcirculation and antagonizing calcium. In the present paper, the anti-adhesion effect of TMP were reviewed. TMP was found to play a multi-target and muti-link role in anti-adhesion by inhibiting hyperplasia of collagen and overexpression of adhesion-related factors and reducing the concentration of white blood cells and fibrin in plasma. Because previous studies mostly focused on in vitro experiments and animal experiments, there is an urgent need for clinical research with abundant indicators to further prove its anti-adhesion potency. Future basic research should concentrate on the development of TMP as a biological material.


tetramethylpyrazine tissue adhesion pharmacological activity review 


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Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine 2018

Authors and Affiliations

  1. 1.Department of Anorectal SurgerySuzhou Hospital of Traditional Chinese MedicineSuzhouChina
  2. 2.First College of Clinical MedicineNanjing University of Chinese MedicineNanjingChina

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