Chinese Journal of Integrative Medicine

, Volume 24, Issue 6, pp 474–480 | Cite as

Research Progress on Reversing Multidrug Resistance in Tumors by Using Chinese Medicine

  • Huan-dong Zhao
  • Hong-juan Xie
  • Jian Li
  • Cai-ping Ren
  • Yu-xiang Chen


Multidrug resistance (MDR) is a major cause of cancer chemotherapy failure, and it is important to develop suitable reversal agents to overcome MDR. A majority of chemical reversal agents have acceptable reversal effects. However, the toxicity and adverse reactions associated with these agents restricts their clinical use. Chinese medicines (CMs) have lower toxicities and adverse reactions and are associated with multiple components, multiple targets and reduced toxicity. CMs have several advantages and could reverse MDR, decrease drug dosage, enhance patient compliance and increase efficacy. This review summarizes the current progress of CM reversal agents..


tumor multidrug resistance reversal agents Chinese medicine 


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Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine 2018

Authors and Affiliations

  • Huan-dong Zhao
    • 1
    • 4
  • Hong-juan Xie
    • 2
  • Jian Li
    • 1
  • Cai-ping Ren
    • 3
  • Yu-xiang Chen
    • 4
  1. 1.Key Laboratory of Nanobiological Technology of Chinese Ministry of Health, Xiangya HospitalCentral South UniversityChangshaChina
  2. 2.Department of Pharmacy, Tongren HospitalShanghai Jiaotong University, School of MedicineShanghaiChina
  3. 3.Cancer Research Institute, Collaborative Innovation Center for Cancer Medicine, Key Laboratory for Carcinogenesis of Chinese Ministry of Health, School of Basic Medical ScienceCentral South UniversityChangshaChina
  4. 4.School of PharmacyCentral South UniversityChangshaChina

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