Chinese Journal of Integrative Medicine

, Volume 24, Issue 9, pp 670–675 | Cite as

Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY-1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction

  • Jin-Woo Jung
  • Seung Hwan Jeon
  • Woong Jin Bae
  • Su Jin Kim
  • Mun Su Chung
  • Byung Il Yoon
  • Sae Woong Choi
  • U. Syn Ha
  • Sung Yeoun Hwang
  • Sae Woong KimEmail author
Original Article



To investigate the anti-oxidative stress and preventive effect of modified Gongjin-dan (WSY-1075) in a detrusor underactivity rat model.


Rats were randomly allocated to three groups: shamoperated (control), bladder outlet obstruction-induced detrusor underactivity (BOO-DU), and BOO-DU with WSY-1075 (WSY) groups. WSY-1075 was orally administrated to rats 200 mg daily for 2 weeks prior to the operation and 4 weeks after the operation. Bladder outlet obstruction was surgically induced in rats by ligation around the urethra avoiding total obstruction. Cystometrography was conducted on rats in each group for examination of bladders.


Compared with the control group, bladder outlet obstruction led to a significant increase in oxidative stress with consequent changes to molecular composition, and decrease in maximal detrusor pressure (P<0.05). WSY-1075 treatment significantly suppressed oxidative stress and prevented degenerative and dysfunctional changes in bladder, as compared with BOO-DU group (P<0.05).


WSY-1075 had beneficial effect on prevention of BOO-DU.


detrusor underactivity anti-oxidant herbal 


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Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine 2017

Authors and Affiliations

  • Jin-Woo Jung
    • 1
    • 2
  • Seung Hwan Jeon
    • 3
  • Woong Jin Bae
    • 3
    • 4
  • Su Jin Kim
    • 3
  • Mun Su Chung
    • 1
  • Byung Il Yoon
    • 1
  • Sae Woong Choi
    • 3
  • U. Syn Ha
    • 3
  • Sung Yeoun Hwang
    • 5
  • Sae Woong Kim
    • 3
    • 4
    Email author
  1. 1.Department of Urology, International St. Mary’s HospitalCatholic Kwandong University College of MedicineIncheonRepublic of Korea
  2. 2.Institute for Bio-Medical Convergence, College of MedicineCatholic Kwandong University, GangneungsiGangwon-doRepublic of Korea
  3. 3.Department of Urology, College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea
  4. 4.Catholic Integrative Medicine Research Institute, College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea
  5. 5.Korea Bio Medical Science InstituteSeoulRepublic of Korea

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